Study of Bronchiectasis and Chronic Respiratory Infections in Children and Adults to Understand Its Causes and Progression

What this Trial Is About

Bronchiectasis is a condition marked by inflamed, abnormally widened airways prone to chronic and recurring infections affecting the respiratory tract including sinuses, ears, and lungs. This condition remains a major concern in certain populations, such as those with cystic fibrosis, and continues to pose challenges in developing countries. Researchers are studying bronchiectasis to understand inherited and immune factors that cause some individuals to experience ongoing infections. This observational study involves patients aged 5 years and older with bronchiectasis or chronic respiratory infections, along with some of their direct family members. Participants will undergo evaluations including medical history reviews, respiratory symptom questionnaires, and standard procedures like nasal air sampling, lung imaging, lung function tests, and collection of blood, urine, and sputum samples. Family members may provide blood or cheek swab samples for genetic testing. Patients will continue to receive standard care to prevent infections and disease progression during the study. Participants will be seen at least every six months for the first two years and then at intervals ranging from one to five years, continuing for up to five years or until they choose to stop. During visits, researchers will monitor disease progression and gather information on factors linked to bronchiectasis. Assessments include clinical evaluations, questionnaires, imaging, lung function tests, and sample collections. The study aims to identify causes of bronchiectasis and to better understand its development and management over time.

Natural History of Bronchiectasis