Prevalence of malocclusion and orthodontic treatment need in the United States: estimates from the NHANES III survey.
W R Proffit, H W Fields, L J Moray
https://pubmed.ncbi.nlm.nih.gov/9743642Actively Recruiting
Age: 2Years - 100Years
All Genders
Healthy Volunteers
ID02639312
Natural History of Craniofacial Anomalies and Developmental Growth Variants
Led by National Institute of Dental and Craniofacial Research (NIDCR) · Updated on 2026-03-17
2400
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand the development of craniofacial anomalies, which are conditions affecting the face, head, and neck. These anomalies vary from rare birth defects to more common developmental differences that appear around puberty. The study focuses on identifying genetic variants and creating a detailed database to better characterize these conditions and their impact on growth and facial structure. It includes both individuals with these abnormalities and comparisons with family members and healthy volunteers. Participants include people with craniofacial anomalies, unaffected family members, and healthy volunteers. The study involves multiple visits at key developmental stages: ages 2-6, 6-10, 11-17, and 18 and older. Visits may include medical history review, physical and oral exams, questionnaires, blood and urine tests, cheek swabs, cone beam CT scans, and photos. Offsite participants provide medical and dental records, leftover tissue samples, and biological samples. Participants may be followed for several years, with some visits requiring a few days near the clinic. Researchers will assess physical features using clinical evaluations and imaging techniques, while genetic data will be collected and analyzed. The main outcome is the creation of a comprehensive database of phenotypic and genetic information. This long-term study helps link clinical care with genetic understanding of craniofacial disorders.
CONDITIONS
Brief Title
Natural History of Craniofacial Anomalies and Developmental Growth Variants
Who Can Participate
Age: 2Years - 100Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age greater than 2 years and less than 100 years with craniofacial anomalies or abnormalities
- Able to provide consent or have a legally authorized representative provide consent for minors
- Unaffected family members aged 2 to 100 years with a family relationship to a subject with craniofacial anomalies
- Healthy volunteers aged 6 to less than 100 years in good general health
- Healthy volunteers must have no craniofacial congenital anomalies, malocclusion, or family history of craniofacial syndromes
- Consent or legally authorized representative consent for all participants
You will not qualify if you...
- History of facial trauma requiring surgical treatment and reconstruction
- Refusal to participate in both genetic testing and cone beam CT imaging; participation requires agreeing to at least one
- Pregnant or nursing healthy female volunteers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Initial assessment period
Participants undergo extensive clinical evaluations including 3D cone-beam computed tomography-based geometric morphometric, cephalometric analyses, and surface morphology to characterize craniofacial anomalies.
1 to 2 visits depending on the extent of evaluations
Long-term Monitoring
Duration - Up to 17 years
Participants are followed over time to collect and update phenotypic and genetic data related to craniofacial anomalies and developmental growth variants.
Periodic visits as scheduled for ongoing assessments
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
P
Pamela M Orzechowski, R.N.
K
Konstantinia Almpani, D.D.S.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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S Frazier-Bowers, R Rincon-Rodriguez, J Zhou...
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Ermina Lee, Marcus Crayton, Janice S Lee...
https://pubmed.ncbi.nlm.nih.gov/41460808