Study on Treatment and Outcomes for Depression, Bipolar Disorder, and Suicide Risk

What this Trial Is About

Researchers are studying mood disorders including depression, bipolar disorder, and suicide risk to better understand how these conditions affect individuals and their response to treatment. The study focuses on people aged 18 and older who are receiving treatment for these conditions and were also enrolled in a previous protocol. The goal is to identify factors that predict how patients respond to antidepressant treatments and to understand changes in suicidal thoughts. Participants will undergo personalized treatments for their mood disorders and receive standard clinical care that may be adjusted based on their needs. The study involves weekly interviews and questionnaires during treatment, with optional psychological tests, blood draws, sleep studies, and brain imaging performed at the beginning and end of participation. The study typically lasts up to 12 weeks but can be longer if treatment continues. During the study, participants will be regularly assessed using clinical rating scales such as the Montgomery Asberg Depression Rating Scale and the Scale for Suicidal Ideation. Data collection includes both in-person and remote evaluations. Researchers will monitor treatment effects and collect biological data to find predictors and biomarkers of treatment response. The study is conducted at the NIH Clinical Center and aims to support future improvements in managing mood disorders.

Natural History of Depression, Bipolar Disorder and Suicide Risk