Natural History of Depression, Bipolar Disorder and Suicide Risk

What this Trial Is About

Researchers are studying people with mood disorders, including depression, bipolar disorder, and those at risk of suicide, to better understand how these conditions affect the body and how different treatments work. The study aims to identify predictors of response to antidepressant treatment and to find ways to predict which medications may help reduce thoughts of suicide. This observational study is conducted by the National Institute of Mental Health and involves participants who are already receiving clinical care for these conditions. Participants in this study are adults aged 18 years or older who have previously enrolled in a related protocol. They will undergo personalized treatments for their mood disorders and will be closely monitored through clinical ratings both in-person and remotely. The study includes three groups: individuals with bipolar disorder, individuals with major depressive disorder, and individuals at elevated suicide risk. The study typically lasts up to 12 weeks but may continue longer if treatment extends beyond this period. During the study, participants will have weekly interviews and complete questionnaires to assess their mood and suicidal thoughts. Optional tests such as psychological assessments, blood draws, sleep studies, and imaging scans are performed at the beginning and end of participation. The main outcomes measured are scores on the Montgomery Asberg Depression Rating Scale and the Scale for Suicidal Ideation, collected weekly. This helps researchers track treatment effects and understand the biological and clinical factors influencing response to therapy.

Natural History of Depression, Bipolar Disorder and Suicide Risk