Actively Recruiting
Natural History of Depression, Bipolar Disorder and Suicide Risk
Led by National Institute of Mental Health (NIMH) · Updated on 2026-04-29
500
Participants Needed
1
Research Sites
298 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments. In this study, researchers want to perform tests on people undergoing clinical care for mood disorders. The purpose is to understand the experience of receiving treatment for depression, bipolar disorder, and suicide risk. We also hope that this study will help us to predict which medications will improve thoughts of suicide. People 18 years or older who are receiving treatment for depression, bipolar disorder, or suicide risk may take part in this study. Participants must have also been enrolled in protocol 01-M-0254. This study will be conducted at the NIH Clinical Center in Bethesda, MD. The study typically lasts up to 12 weeks, but may last longer if a participant s treatment continues past that time. Participants will have weekly interviews and questionnaires while they are being treated for their mood disorder. Other tests are optional and include psychological testing, blood draws, sleep tests, and imaging scans. These will be done at the start and the end of research participation.
CONDITIONS
Official Title
Natural History of Depression, Bipolar Disorder and Suicide Risk
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed consent for Protocol 01-M-0254: The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers
- Age 18 years or older
- Able to provide informed consent
- Able to read and write English
You will not qualify if you...
- Unstable medical conditions that would prevent outpatient or inpatient treatment
- Pregnancy
- Participation as a healthy volunteer in Protocol 01-M-0254
- History of recent substance or alcohol abuse or dependence (except caffeine, nicotine, or cannabis) within the past three months
- Current use of illicit substances or known drugs of abuse within two weeks prior to consent, except prescribed benzodiazepines or stimulants
- Daily cannabis use, inability to abstain during the study, or cannabis use that impairs daily life functioning as determined by a clinician
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
K
Kelly T Hurst, Ph.D.
CONTACT
E
Elizabeth D Ballard, Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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