Actively Recruiting
Natural History and Development of Spondyloarthritis
Led by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · Updated on 2026-05-07
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- Spondyloarthritis (SpA) is a group of bone and joint disorders that may cause back and joint pain and stiffness. In some cases, SpA can lead to abnormal bone growth affecting the joints and spine. Some patients have SpA without ever developing these growths, while others develop them after only a few years. Researchers are interested in studying people with SpA and their relatives to determine which people are more likely to develop more severe conditions. Objectives: \- To identify symptoms and medical tests that can help determine whether a person with SpA is at risk for developing more severe forms of the disease. Eligibility: * Individuals of any age who have been diagnosed with SpA. * Healthy volunteer relatives (at least 6 years of age) of the individuals with SpA. Design: * Participants will be screened with medical records and family medical histories, and will be invited to the clinical center for the study. * Participants with SpA will have a physical exam and medical history, including a study of joint movement, blood and urine tests, and questionnaires about pain and quality of life. * Participants with SpA will have imaging studies, including magnetic resonance imaging (MRI). Other samples such as skin tissue and bone marrow may also be collected for study. * Healthy volunteers will provide a blood sample and cheek cell samples. * No treatment will be provided, although treatment options will be discussed.
CONDITIONS
Official Title
Natural History and Development of Spondyloarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with known or suspected spondyloarthritis (SpA)
- Family members of individuals with known or suspected SpA
- Healthy volunteers 6 years of age or older serving as controls
- Minor healthy volunteers must be able to complete imaging procedures without sedation
- Pregnant people with SpA may enroll but will not undergo MRI, skin biopsy, or bone marrow aspiration
- Participants must provide informed consent or have guardian consent if minors
You will not qualify if you...
- Inability to provide informed consent or lack of available parent/guardian for minors
- Any medical condition that could confuse study interpretation
- Inability or unwillingness to comply with follow-up visit schedule
- Children under 2 years old
- Children under 6 years with acute or chronic comorbidities preventing safe evaluation at the clinic
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Sahar Lotfi-Emran, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here