Study on the Natural History and Causes of Spondyloarthritis in Children and Adults Including Family Members and Healthy Volunteers

What this Trial Is About

Researchers are studying spondyloarthritis SpA, a group of bone and joint disorders that cause pain and stiffness and may lead to abnormal bone growth affecting joints and the spine. This study aims to understand which people with SpA or their relatives are more likely to develop severe forms of the disease by evaluating symptoms, medical tests, and genetic factors. The study includes both children and adults with SpA as well as healthy relatives and volunteers. Participants with SpA will undergo detailed evaluations including physical exams, medical history reviews, joint movement assessments, blood and urine tests, questionnaires on pain and quality of life, and imaging studies such as MRI and X-rays. Additional samples like skin tissue, bone marrow, and stool may be collected for research. Healthy volunteers will provide blood and cheek cell samples. No treatments are given during the study, but treatment options may be discussed. Throughout the study, participants will be followed over time to monitor disease progression, including the development of axial SpA and ankylosing spondylitis. Researchers will collect clinical data, imaging results, and biomarkers, and may perform genetic testing and stem cell studies. The primary outcome is tracking progression over 10 years, with ongoing assessments of disease activity and function. This long-term observation will help improve understanding of SpA and inform future treatment research.

Natural History and Development of Spondyloarthritis