Actively Recruiting
Studies of the Natural History, Pathogenesis and Outcome of Ocular Disorders
Led by National Eye Institute (NEI) · Updated on 2026-05-29
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the natural history, causes, and outcomes of various eye diseases in this observational study conducted by the National Eye Institute (NEI). The study aims to better understand eye diseases, including how they are inherited, by examining individuals with diagnosed, undiagnosed, or suspected eye conditions as well as their first-degree relatives. The research seeks to collect clinical data and specimens to aid future studies and assess responses to standard treatments. Participants may have between 1 and 12 visits per year for up to 5 years, depending on their eye condition. Each visit lasts about 4 hours and may include medical and family history review, physical exams, eye exams with photography, and specialized tests such as oculography, electrooculography, electroretinography, and fluorescein angiography. Samples collected may include eye cell swabs, blood, skin, tear, urine, saliva, stool, or hair. Treatments like medications, eye drops, injections, laser therapy, or surgery may be provided as clinically indicated. During the study, participants will undergo various assessments including eye imaging and functional testing with devices, laboratory tests, and possibly exams under anesthesia for some children. Researchers will monitor clinical outcomes based on standard care treatments without formal outcome measures. Participants' adherence and health status will be evaluated regularly through these visits to understand disease progression and treatment effects over time.
CONDITIONS
Brief Title
Natural History, Pathogenesis, and Outcome of Ocular Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a diagnosed, undiagnosed, or suspected eye disease.
- Ability to understand and sign informed consent or have a parent/legal guardian or authorized representative provide consent.
You will not qualify if you...
- Unwillingness to give informed consent or assent when applicable.
- Unwillingness or inability to be followed as clinically indicated.
- Presence of systemic disease that compromises adequate ophthalmologic examination or treatment by NEI clinicians.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Ongoing throughout clinical care
Participants who undergo routine care are observed through clinical assessments and specimen collection to understand the natural history and outcomes of ocular disorders.
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
A
Awilda V Holland, R.N.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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