Study of Eye Diseases to Understand Their Course, Causes, and Treatment Outcomes

What this Trial Is About

Researchers are studying people with diagnosed, undiagnosed, or suspected eye diseases to better understand these conditions and how they are inherited. The study also includes first-degree relatives without symptoms who agree to provide blood samples for genetic testing. The goal is to collect clinical data and specimens from participants receiving standard eye care, helping to build resources for future research and evaluate current treatments. Participants may have between 1 and 12 visits annually for up to 5 years, depending on their eye condition. Each visit lasts about 4 hours and can include medical and family history reviews, physical and eye exams, eye photography, specialized eye movement and electrical tests, and imaging with dye injections. Samples from the eye surface, blood, skin, tears, urine, saliva, stool, or hair may be collected. Some children may have exams done under anesthesia. Treatments such as medications, eye drops, injections, laser therapy, or surgery may be given during these visits. During the study, participants undergo various assessments including eye exams, photography, and specialized tests like electroretinography and fluorescein angiography. Researchers monitor responses to standard treatments through these clinical evaluations. The study involves ongoing data collection and specimen gathering to understand the natural history of eye diseases and treatment effects. Participation may last up to 5 years, with regular follow-up visits tailored to the participants condition.

Natural History, Pathogenesis, and Outcome of Ocular Disorders