Actively Recruiting
Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-03-13
1590
Participants Needed
1
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: People who get COVID-19 have a wide range of symptoms. They also recover from COVID-19 in different ways. In this study, researchers will use survey data to describe the different ways people experience and recover from COVID-19. They will also use the data to help create future studies to understand why some people do not fully recover. Objective: To learn more about the range and timing of symptoms that people have before, during, and after COVID-19 infection. Eligibility: People ages 18 and older who can give documentation of a positive COVID-19 or antibody test. Design: Participants will be screened with a telephone interview. It will take 15 minutes. They will provide their COVID-19 test results and medical records. Participants will complete a second telephone interview. It will take 30 60 minutes. They will also take online surveys every 3 months for 3 years. The interview and surveys will ask participants about their health before they got COVID-19, what happened while they had COVID-19, and what their recovery has been like. Participants will get log-in data to take the online surveys. Completing all of the surveys the first time may take up to 3 hours. Follow-up surveys will take up to 30 minutes. Participants do not have to complete the surveys in one sitting. They will be able to save their progress and finish the surveys later. Participants may be contacted to take part in other research studies.
CONDITIONS
Official Title
Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants 18 years or older
- Ability to provide informed consent
- Willingness to complete telephone interviews
- Started recovery from acute SARS/CoV2 infection within the past 5 years or meet specific criteria for persistent symptoms or vaccine-related conditions
- Provide documentation of positive COVID-19 test or clinical diagnosis as applicable
- For Phase B: completion of at least 7th grade, fluency in English, primary care provider, at least 6 weeks since symptom onset, no active infection
- Meet criteria for mild to moderate COVID-19 illness with varying severity of post-acute symptoms as defined in study
- For Phase C: meet Phase B criteria and no alternative explanation for symptoms, fluency in English
You will not qualify if you...
- Unwillingness to provide personal identifying information
- Severe cognitive impairment limiting consent capacity
- Current or past psychotic disorders
- Unmanaged major depression, anxiety, PTSD, panic disorder, or OCD within 6 months
- Substance use disorder in last 5 years except marijuana
- Positive urine drug screen for non-prescribed substances (some exceptions)
- Current suicidal thoughts
- History of moderate or severe traumatic brain injury
- Pregnant, breastfeeding, or within one year postpartum
- Current or previous malignancy except fully resolved by surgery only
- Systemic immunologic disorders (some exceptions)
- Long-term immune suppressive therapy
- Medical conditions causing fatigue or exercise intolerance that exclude Phase C participation
- Participation in other clinical studies affecting results
- Unwillingness to share data broadly
- NIH employees under direct supervision of study investigators
- Symptom severity preventing travel to NIH
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
A
Angelique A Gavin
CONTACT
B
Brian T Walitt, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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