Periodic Illness Associated With Epstein-Barr Virus: A New Diagnosis After a 22-Year Follow-up.
Lesia K Dropulic, Mir A Ali, Amanda K Ombrello...
https://pubmed.ncbi.nlm.nih.gov/27025823Actively Recruiting
Age: 2Years - 100Years
All Genders
ID01011712
The Natural History of Severe Viral Infections and Characterization of Immune Defects
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-06-01
600
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating why some individuals without known immune system problems develop severe, persistent, or hard-to-treat viral infections. These infections include those caused by herpesviruses, papillomaviruses, adenoviruses, polyomaviruses, and influenza viruses. The study aims to identify immune or genetic defects that may make these infections more severe, helping to better understand the immune system and potentially guide new treatments. Participants include children and adults diagnosed with unusually severe viral infections, as well as their relatives, who may also join to help scientists understand if immune defects run in families. The study involves reviewing medical records and providing optimal therapy for the viral infection at the NIH Clinical Center. During the study, blood samples and skin biopsies may be taken to analyze the immune system, and researchers will monitor how the infection responds to treatment. Participants will have follow-up visits during and after their illness to track the infection's course and treatment response. The study includes detailed evaluations, laboratory tests, and specimen storage for future research. The primary goal is to identify immune or genetic factors linked to severe viral infections over a period of up to 10 years, with ongoing monitoring to understand these infections better.
CONDITIONS
Brief Title
The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunocompromise
Who Can Participate
Age: 2Years - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
- Children or adults with a diagnosed severe or unusual viral infection, including herpesviruses, papillomaviruses, adenoviruses, calicivirus, polyomaviruses, or influenza virus
- Children or adults who have recovered from a severe, persistent, or treatment-resistant viral infection
- Ongoing care by a referring physician
- Willingness to allow storage of blood and tissue samples for future analysis
- Male and female relatives aged 2 years or older may participate to help study genetic factors
- Relatives may be healthy or show signs of immune system issues
- Adult relatives or guardians must provide informed consent for participation
You will not qualify if you...
- Patients with known acquired or treatment-related immune deficiency, such as HIV infection or those receiving chemotherapy or high-dose steroids
- Women who are pregnant
- Any major health condition that would prevent compliance with the study requirements, as judged by the investigators
- Patients on immunosuppressive or immunomodulatory therapy for immune system disorders may be included only at the investigator's discretion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 10 years
Participants with severe or unusual viral infections are observed to investigate immune and genetic factors that may predispose them to these infections over an extended period.
Visits occur as needed during routine care and follow-up assessments
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Loading map...
Research Team
K
Kayla D Morgan
J
Jessica R Durkee-Shock, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.
Emily M Mace, Amy P Hsu, Linda Monaco-Shawver...
https://pubmed.ncbi.nlm.nih.gov/23365458Severe viral infections and primary immunodeficiencies.
Lesia K Dropulic, Jeffrey I Cohen
https://pubmed.ncbi.nlm.nih.gov/21960712