Evaluation, Pathogenesis, and Treatment of Patients With or at Risk for Cerebrovascular Disease A Natural History and Disease Pathogenesis Protocol

What this Trial Is About

Researchers are studying stroke and related cerebrovascular diseases to better understand their natural history and develop ideas for future research. This observational study includes patients aged 18 and older who have experienced or are at risk for acute stroke or transient ischemic attacks (TIA). The study aims to establish a detailed registry with clinical, laboratory, and imaging data to explore relationships among disease characteristics and outcomes. Participants undergo standard medical care tests such as blood and urine analyses, EKG, CT scans, MRI, Transcranial Doppler, and echocardiograms. Some tests may be repeated at follow-up visits scheduled at 1, 3, and 12 months to observe changes over time. Research-specific blood and urine samples are also collected to assess biomarkers and gene expression related to stroke. Throughout the study, participants will be monitored with imaging studies to identify abnormalities linked to stroke severity and progression. Clinical assessments include stroke severity scales and functional outcome measures. Data collection also involves evaluating gene expression and biomarkers from blood samples. The total participation time can extend up to a year with multiple follow-up assessments to track recovery and disease progression.

Natural History of Stroke: Cause and Development