Characterization of hearing-impairment in Generalized Arterial Calcification of Infancy (GACI).
Elizabeth H Theng, Carmen C Brewer, Ralf Oheim...
https://pubmed.ncbi.nlm.nih.gov/35854274Actively Recruiting
Age: 1Day - 100Years
All Genders
ID00024804
A Natural History Study of Bone and Mineral Disorders
Led by National Institute of Dental and Craniofacial Research (NIDCR) · Updated on 2026-05-28
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying individuals with bone and mineral disorders to better understand these conditions and improve knowledge about bone biology. The study allows patients with various skeletal diseases to be evaluated and treated at the NIH Clinical Center, while also offering training opportunities for NIH trainees. The research includes collecting bone specimens from patients to support further study of bone diseases. Participants receive evaluations that include medical history reviews, physical exams, and standard tests such as blood and urine analysis, X-rays, bone densitometry, bone scans, CT scans, and MRI. Bone samples may be collected either from tissue removed during planned surgical procedures or via bone biopsy as part of the evaluation. No experimental treatments or tests are involved; all procedures are part of routine care for skeletal diseases. Throughout the study, patients undergo clinical assessments tailored to their diagnosis at specific times. Researchers collect and analyze clinical data and biological specimens, including genetic and biochemical tests on surgical waste material. The study aims to build a database containing detailed information and specimens from participants to support future research. Participation duration and specific assessments vary depending on each participant's condition and needs.
CONDITIONS
Brief Title
A Natural History Study of Bone and Mineral Disorders
Who Can Participate
Age: 1Day - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age 1 day or older
- Have a known or suspected bone disease demonstrated by a fracture, abnormal bone imaging, or relevant medical or family history
- Have a known or suspected disorder of mineral metabolism shown by abnormal laboratory values or consistent medical or family history
You will not qualify if you...
- Unwilling or unable to follow the procedures of the protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Up to 10 years
Participants undergo medical evaluations and clinical assessments specific to their bone and mineral disorder diagnosis. Clinical and research specimens are collected during this time.
Visits scheduled based on individual diagnosis and clinical needs
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
E
Elizabeth A Ferguson
K
Kelly B Roszko, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Frequently Asked Questions
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