What is this study trying to find out about bone and mineral disorders?

This study aims to understand various bone and mineral disorders by evaluating affected individuals and collecting tissue samples. Researchers want to improve knowledge of these conditions and create a resource for future research. The study is sponsored by the National Institute of Dental and Craniofacial Research.

Who may be eligible for this bone and mineral disorders clinical trial?

Individuals aged 1 day to 100 years with known or suspected bone diseases or mineral metabolism disorders may be eligible. There are no gender restrictions. Participants must be able to follow study procedures. Please review eligibility criteria for more details.

Is there any cost to participate in this bone and mineral disorders clinical trial?

Study-related care, including evaluations and procedures, is provided at no cost. However, personal expenses such as travel may vary and are not guaranteed to be covered. Participants can plan accordingly based on their situation.

Actively Recruiting

Age: 1Day - 100Years

All Genders

ID00024804

Natural History Study Investigating Bone and Mineral Disorders in Patients Aged 1 Day to 100 Years

Led by National Institute of Dental and Craniofacial Research (NIDCR) · Updated on 2026-08-04

1000

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to study and treat individuals with various bone and mineral disorders at the NIH Clinical Center. It provides an opportunity to collect bone specimens for research and to increase knowledge of skeletal diseases, supporting further studies in bone biology. Participants include those with both common and rare bone and mineral metabolism disorders, with evaluations tailored to each diagnosis. Participants receive standard care evaluations and treatments for their bone conditions, without experimental procedures. Assessments include medical history, physical exams, blood and urine tests, and imaging such as X-rays, CT scans, MRIs, bone densitometry, and bone scans. Bone samples may be collected during planned surgeries or through bone biopsies as part of participant evaluation. Throughout the study, participants undergo medical assessments and specimen collection at times specific to their diagnosis. Researchers analyze clinical and research specimens, including genetic and biochemical evaluations of surgical waste materials. The study also aims to create a database of participant information and biological samples to support future research. Participation duration and specific procedures vary by individual needs.

CONDITIONS

Brief Title

A Natural History Study of Bone and Mineral Disorders

Who Can Participate

Age: 1Day - 100Years

All Genders

Eligibility Criteria

You may qualify if you...

Age 1 day or older
Known or suspected bone disease demonstrated by fracture, abnormal bone findings on imaging, or medical/family history
Known or suspected disorder of mineral metabolism demonstrated by abnormal laboratory values or medical/family history

You will not qualify if you...

Unable or unwilling to follow the study procedures

Research Team

Elizabeth A Ferguson

Kelly B Roszko, M.D.

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