Study of Medullary Thyroid Cancer and MEN2 in Children and Adults to Understand Disease and Effects Over Time

What this Trial Is About

Medullary thyroid cancer MTC is a rare type of thyroid tumor that often occurs as part of Multiple Endocrine Neoplasia 2 MEN2, a genetic condition. MEN2 can cause other health issues such as adrenal gland tumors and hormone changes. Researchers are studying how MTC affects children and adults over time, especially in those with MEN2, to better understand the diseases progression and its impact on growth and development. This observational study will follow children and adults diagnosed with MTC or MEN2, with or without MTC, over several years. Participants will have regular visits every 6 to 12 months, during which clinical exams, blood tests, imaging, and other evaluations will be performed as needed. Additionally, tissue samples will be analyzed to study molecular changes, and caregivers of young patients will provide information about psychosocial experiences. No experimental treatments are given as part of this study participants continue standard care and may join other clinical trials. During the study, participants will undergo clinical and radiological assessments along with molecular analyses of tumor samples. Questionnaires about health and emotional well-being will be completed by patients and caregivers. Researchers will monitor tumor growth rates and molecular pathways involved in MTC, as well as non-tumor effects of MEN2. The study aims to gather detailed information over five years to better understand the disease and improve future interventions.

Natural History Study of Children and Adults With Medullary Thyroid Cancer