Actively Recruiting
Natural History Study of Children and Adults With Medullary Thyroid Cancer
Led by National Cancer Institute (NCI) · Updated on 2026-03-27
259
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- Medullary thyroid cancer (MTC) is a rare cancer of the thyroid gland. In children and adults, it is often part of a condition called Multiple Endocrine Neoplasia 2 (MEN2). MEN2 is usually caused by a genetic mutation, and it can cause a number of problems in addition to MTC. These problems include adrenal gland tumors, hormone changes, and problems with the bones and other organs. Not much is known about how MTC develops over time, especially in people with MEN2. Researchers want to study MTC in children and adults and see how it affects their growth and development. Objectives: \- To study how medullary thyroid cancer affects children and adults over time. Eligibility: \- Children and adults who have medullary thyroid cancer. Design: * Participants will be screened with a brief physical exam and medical history. Blood and tissue samples will be collected to see whether participants have the MEN2 genetic mutation. * Treatment will not be provided as part of this study. However, participants will be receiving standard care for MTC. They may be eligible for other clinical trials at the National Institutes of Health. * Participants will have regular study visits every 6 to 12 months to evaluate their MTC and any treatment. Blood tests, imaging studies, and other tests may be performed as needed to monitor the disease. * Participants and their parents/guardians will also complete questionnaires about their health and emotions during the study.
CONDITIONS
Official Title
Natural History Study of Children and Adults With Medullary Thyroid Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with histologically or cytologically confirmed medullary thyroid cancer (MTC) confirmed by the NCI Laboratory of Pathology OR diagnosed with MEN2A or MEN2B regardless of MTC presence
- Ability to travel to the NIH and undergo study evaluations
- Ability of patient or legal guardian (if under 18) to understand and sign informed consent
- Patients may have prior, current, or no medical or surgical treatment for MEN2-related conditions
- Patients must have a primary care provider to coordinate medical care
- Parents or primary caregivers of patients under 21 with confirmed MTC or MEN2 who can provide informed consent
You will not qualify if you...
- Patients unable to return for follow-up visits or complete required follow-up studies as determined by the investigator
- No exclusion criteria for parents or primary caregivers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
A
Andrea N Lucas
CONTACT
J
John W Glod, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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