Actively Recruiting
A Natural History Study of Metabolic Sizing in Health and Disease
Led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Updated on 2026-05-18
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how metabolism relates to body composition and body surface area BSA in a wide range of people, including healthy individuals and those with conditions like diabetes, obesity, kidney disease, or cancer. They aim to find more accurate ways to measure metabolism and understand how measured BSA compares to estimates based on height and weight. This observational natural history study is sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases NIDDK. Participants will spend 2 days and 1 night in the hospital for testing. They will provide medical history and information about their activity, diet, and lifestyle, and consume a special diet during the stay. Tests include lying under a clear hood to measure breath gases, body scanning while lying down and standing, measuring electrical signals through the body, hand strength tests, and providing blood and urine samples after drinking salty water. Participants may return for up to 8 such visits per year, with at least 2 weeks between visits. During the study, researchers will monitor resting energy expenditure, body composition, and BSA through these tests and questionnaires. They will track differences between measured and predicted BSA and how BSA relates to energy use. Safety and ability to complete tests are monitored, and the total participation time depends on the number of visits. This detailed assessment helps understand metabolism across health and disease states.
CONDITIONS
Brief Title
A Natural History Study of Metabolic Sizing in Health and Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 2 years or older
- For healthy volunteers: in good general health as shown by medical history
- For patients: diagnosed with diseases or taking medications that may alter metabolism or body composition, such as diabetes, renal disease, obesity, or cancer
You will not qualify if you...
- Weighing over 200 kg due to equipment limits
- Having any implanted device that interferes with measurements
- Moderate to severe mobility limitations preventing participation
- Hemoglobin less than 10 g/dL if blood will be drawn
- Dietary allergies, intolerances, or eating patterns preventing consumption of study meals
- Unable or unwilling to give informed consent
- Any other significant physical, medical, or psychiatric condition that could prevent completion of study tests per investigator's discretion
Research Team
M
Margaret S McGehee, C.R.N.P.
K
Kong Y Chen, Ph.D.
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