Study of Parathyroid Disorders to Understand Their Causes and Long-Term Effects Including Related Conditions and Genetic Factors

What this Trial Is About

Researchers are studying parathyroid disorders, which involve problems with parathyroid hormone affecting calcium and phosphate balance in the body. The study aims to investigate the causes, including genetic factors, and to understand how these disorders develop and change over time, especially in syndromic cases like multiple endocrine neoplasia and hyperparathyroidism-jaw tumor syndrome. Participants with confirmed, suspected, or risk factors for parathyroid or related disorders will receive standard medical care and testing. Samples such as saliva, blood, urine, stool, cheek cells, and sometimes skin biopsies may be collected for research. Medical photos and leftover tissue from surgeries may also be obtained. Care and visits may happen in person or via telehealth. During the study, participants will undergo medical evaluations, complete questionnaires about their physical, mental, and social health, and provide various biological samples. Researchers will study biomarkers and molecular profiles over up to five years to learn about the disease cause and progression. Participants remain in the study as long as they receive care from their doctors, with monitoring of clinical and molecular outcomes.

Natural History Study of Parathyroid Disorders