Actively Recruiting

Age: 0Years - 18Years
All Genders
NCT05112237

Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy

Led by Tenaya Therapeutics · Updated on 2024-11-13

200

Participants Needed

29

Research Sites

343 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The objective of this study is to collect information on patients with cardiomyopathy (CM) due to mutations in the MYBPC3 gene, to evaluate their disease course, burden of illness, risk factors for this disease, and the quality of life (QoL). This study will also collect information on treatments, procedures and outcome in infants and children up to 18 yrs who have this mutation.

CONDITIONS

Official Title

Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy

Who Can Participate

Age: 0Years - 18Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient is under 18 years of age at enrollment or at time of death
  • Documented genotyping results showing at least one pathogenic or likely pathogenic MYBPC3 mutation (heterozygous, homozygous, or compound heterozygous)
  • Infants who are homozygous or compound heterozygous for known pathogenic truncating MYBPC3 mutations are eligible (prospective group)
  • Diagnosis of cardiomyopathy including hypertrophic, dilated, restrictive, mixed, or left ventricular noncompaction cardiomyopathy (prospective group)
Not Eligible

You will not qualify if you...

  • Patient received cardiac transplantation or died more than 10 years before study start (except homozygous or biallelic infants, who may have data collected beyond 10 years)
  • Concurrent participation in an interventional clinical trial without sponsor approval
  • Severe noncardiac disease expected to significantly reduce life expectancy

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 29 locations

1

Arkansas Children's Hospital

Little Rock, Arkansas, United States, 72202

Actively Recruiting

2

Children's Hospital Los Angeles

Los Angeles, California, United States, 90027

Actively Recruiting

3

University of California Davis Health

Sacramento, California, United States, 95817

Actively Recruiting

4

Rady Children's Hospital - San Diego

San Diego, California, United States, 92123

Actively Recruiting

5

University of Colorado Hospital - Anschutz Medical Campus

Aurora, Colorado, United States, 80045

Actively Recruiting

6

Nemours Alfred I. Dupont Hospital for Children

Wilmington, Delaware, United States, 19803

Actively Recruiting

7

Joe DiMaggio Children's Hospital

Hollywood, Florida, United States, 33021

Actively Recruiting

8

Children's Mercy Hospital Kansas

Kansas City, Missouri, United States, 64108

Actively Recruiting

9

St. Louis Children's Hospital

St Louis, Missouri, United States, 63110

Actively Recruiting

10

Cohen Children's Medical Center

Lake Success, New York, United States, 11042

Actively Recruiting

11

Mount Sinai

New York, New York, United States, 10029

Actively Recruiting

12

Columbia University Irving Medical Center

New York, New York, United States, 10032

Actively Recruiting

13

Montefiore Medical Center, Albert Einstein College of Medicine

The Bronx, New York, United States, 10467

Actively Recruiting

14

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States, 45229

Actively Recruiting

15

Cleveland Clinic Main Campus

Cleveland, Ohio, United States, 44195

Actively Recruiting

16

DDC Clinic Center for Special Needs Children

Middlefield, Ohio, United States, 44062

Actively Recruiting

17

Cardiology Care for Children

Lancaster, Pennsylvania, United States, 17601

Actively Recruiting

18

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

19

University of Pittsburgh Medical Center - Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States, 15224

Actively Recruiting

20

Children's Medical Center Dallas

Dallas, Texas, United States, 75207

Actively Recruiting

21

Texas Children's Hospital

Houston, Texas, United States, 77030

Actively Recruiting

22

University of Alberta Hospital

Edmonton, Alberta, Canada, T6G 2B7

Actively Recruiting

23

The Hospital for Sick Children

Toronto, Ontario, Canada

Actively Recruiting

24

Hospital Sant Joan de Déu Barcelona

Barcelona, Spain, 8950

Actively Recruiting

25

Hospital General Universitario Gregorio Marañón

Madrid, Spain, 28003

Actively Recruiting

26

Hospital Alvaro Cunqueiro - Clinico Universitario Vigo

Vigo, Spain, 36312

Actively Recruiting

27

NHS Greater Glasgow and Clyde

Glasgow, United Kingdom, G12 0XH

Actively Recruiting

28

Royal Brompton & Harefield NHS Foundation Trust

London, United Kingdom, SW3 6NP

Actively Recruiting

29

Great Ormond Street Hospital for Children NHS Foundation Trust

London, United Kingdom, WC1N 3JH

Actively Recruiting

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Research Team

M

Matthew Pollman, MD

CONTACT

L

LaTanya Tomlinson

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy | DecenTrialz