Actively Recruiting
Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-04-08
150
Participants Needed
1
Research Sites
280 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Influenza (flu) vaccinations are required for all NIH staff members who have direct contact with patients. COVID-19 vaccines are recommended for persons 6 months of age and older. Researchers want to learn about immunity in NIH staff members who get a flu and/or COVID-19 vaccine. Objective: To understand what happens to the body s immune system throughout the year after getting the flu and/or COVID-19 vaccine. Eligibility: Adults ages 18 and older who work at NIH and plan to get the current season s flu vaccine and/or COVID-19 vaccine. Design: Participants will not get any vaccines as part of this study. Participants will be screened with a medical history and medicine review. They will get a survey via email. It will ask about their flu and SARS-CoV-2 history and vaccinations. Participants will have 12 monthly visits at NIH. If during that year they get both flu and SARS-COV-2 vaccines, their participation will be extended. Once a month, participants will be contacted. They will discuss any new medicines, recent vaccinations, or changes in medical history. Once a month, participants will have blood drawn. Once a month, participants will have nasal sampling. A small, flat absorptive strip will be placed in the nostril to soak up mucus. Participants will press against the outside of their nostril with their finger for 1 minute. Participants may be able to collect samples at home and mail them to NIH if they are not able to visit in person. Participation will last for about 12 13 months.
CONDITIONS
Official Title
Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination
Who Can Participate
Eligibility Criteria
You may qualify if you...
- NIH staff members at the time of enrollment
- Able to provide informed consent
- 18 years of age or older
- Planning to receive the current season's influenza vaccine and/or an FDA-authorized or approved COVID-19 vaccine
- Willing and able to undergo blood draws or home blood samplings and nasal sampling procedures
- Willing and able to undergo at least one blood draw and one nasal sampling before receiving vaccine
You will not qualify if you...
- Already received the current season's influenza vaccine and do not plan to receive an FDA-authorized or approved COVID-19 vaccine
- Already received an FDA-authorized or approved COVID-19 vaccine and do not plan to receive the current season's influenza vaccine
- Not willing to receive the current season's influenza vaccine and not willing to receive an FDA-authorized or approved COVID-19 vaccine
- Any condition that, in the opinion of the investigator, contraindicates participation in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
R
Rani S Athota, Ph.D.
CONTACT
A
Alison Han, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here