Actively Recruiting
Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-03-23
1500
Participants Needed
1
Research Sites
1036 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: The right amount of fats in the blood (cholesterol and triglycerides) are a key part of a healthy organism. Too much or too little of these fats may manifest as diseases (dyslipidemia). There are many causes for these abnormalities, but some are genetically determined and we would like to better understand the progression of these conditions over time. Objective: This natural history study aims to learn more about dyslipidemias; how they change over time; and how they respond to therapy. We also want to develop new diagnosis methods for these conditions. With the knowledge we will acquire we hope to provide new insights, new approaches and improve the overall health of these patients. Eligibility: Individuals aged 10 years and older, residing both within and outside the United States, who have or are suspected of having a disorder that causes changes in the levels of fats in their blood (genetic dyslipidemias). Design: Participants residing within and outside the United States will be screened. Their medical records may be reviewed. They may talk to researchers about their medical history by phone, telehealth, or in person. All study visits are optional. Participants may visit the NIH up to 15 times per year, if needed. Each visit may include a physical exam and blood tests. Participants may also have an electrocardiogram (EKG). The EKG measures the electrical activity when the heart beats. In some cases, participants may remain in the study for up to 20 years.
CONDITIONS
Official Title
Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female participants age �3E= 10 years
- Subjects with confirmed or suspected rare disorder causing lipid or lipoprotein abnormalities (dyslipidemia) or abnormal atherosclerosis patterns
- Only affected individuals; subjects with laboratory or clinical presentation that may alter normal assay or screening tool parameters
- Ability to understand and willingness to sign informed consent
- Healthy volunteers with no known lipid disorders or related medical conditions
- Healthy volunteers must not be pregnant
You will not qualify if you...
- Patients with disorders causing common secondary lipoprotein alterations
- Patients with other findings that might prevent participation as determined by the Principal Investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
J
Joy Lynne V Freeman
CONTACT
M
Marcelo J Amar, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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