Actively Recruiting
Nausea Induced by Radiation of the Dorsal Vagal Complex for Benign Brain Tumors (NausiCAA)
Led by University Hospital, Bordeaux · Updated on 2025-07-30
100
Participants Needed
3
Research Sites
210 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients irradiated to the brain frequently experience nausea. The dorsal vagal complex (DVC) area is a specific brainstem zone and has been identified as likely responsible for nausea. Existing clinical studies show correlation between dose to the DVC and nausea, but they concern tumors of the airways and upper digestive tract, where there are many confounding factors. The aim of this study is to establish a ling between radiation dose to the DVC and nausea. Defining a dose threshold to the DVC will allow radiation oncologists to optimize radiation dose distribution and reduce nausea in patients.
CONDITIONS
Official Title
Nausea Induced by Radiation of the Dorsal Vagal Complex for Benign Brain Tumors (NausiCAA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- More than 18 years old
- Diagnosis of benign brain tumor
- Receiving radiation therapy with conventional fractionation (1.8-2 Gy per fraction)
You will not qualify if you...
- History of brain radiation
- History of head and neck radiation
- Dementia
- Receiving concurrent chemotherapy
- Experiencing nausea at time of inclusion
- Using anti-nausea treatments such as corticosteroids, metoclopramide, setrons, or others
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
CHU de Bordeaux, Service de Radiothérapie
Bordeaux, France
Actively Recruiting
2
Hospices Civils de Lyon, Service d'Oncologie Radiothérapie - Hôpital Neurologique
Lyon, France
Not Yet Recruiting
3
Institut de cancérologie Strasbourg Europe (ICANS), Service d'Oncologie Radiothérapie
Strasbourg, France
Not Yet Recruiting
Research Team
C
Charles DUPIN, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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