Actively Recruiting
Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
Led by Murdoch Childrens Research Institute · Updated on 2025-08-27
690
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
POPCORN trial will compare the side effects and effectiveness of Morphine versus Oxycodone medication when prescribed for use as patient controlled analgesia (PCA) for pain relief for paediatric patients after-surgery. This trial is embedded into routine patient care using the hospital electronic medical record (EMR). Participants will be randomly assigned to either medication after they enrol in the study. The main questions the POPCORN trial aims to answer are: * 1\. Is there a difference in the usage of medication to treat nausea and vomiting for those who received oxycodone PCA versus morphine PCA for post-surgery pain relief? * 2\. Is there a difference in side effects or pain relief needed between the two groups? Study activities are as follows: * Participants enrolled to study during their pre-operative consultation * Participants are randomly assigned to morphine or oxycodone * No further study-specific activities expected from participant after enrolment and randomisation * Participant receives routine medical care as planned * Clinicians record assessments as per routine care in electronic medical record (EMR) * EMR data are extracted as trial data
CONDITIONS
Official Title
Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postoperative patients aged 6 to 18 years suitable for PCA
- Patients deemed appropriate for morphine or oxycodone by their anesthetist
- American Society of Anaesthesiologists (ASA) physical status score between 1 and 3
- Informed consent provided by parent or legal guardian
You will not qualify if you...
- Allergy, hypersensitivity, or contraindication to morphine or oxycodone
- Significant intellectual disability or physical incapacity preventing PCA use
- ASA score of 4 or higher
- Parent or legal guardian unwilling or unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Royal Children's Hospital
Melbourne, Victoria, Australia, 3052
Actively Recruiting
Research Team
J
Justine Adams
CONTACT
S
Suzette Sheppard
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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