Actively Recruiting
Navigation Interventions to Improve Cascade Genetic Testing Among Relatives of Patients With Hereditary Cancer Syndromes
Led by University of Michigan Rogel Cancer Center · Updated on 2025-10-16
500
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial tests whether various web-based tools can help improve communication about hereditary cancer risk in families and decrease barriers to genetic testing for relatives of patients with hereditary cancer syndromes. Between 5% and 10% of all cancers are caused by genetic changes that are hereditary, which means that they run in families. Some kinds of cancer or certain cancers diagnosed in biological relatives may mean patients are more likely to have a genetic change. Once a genetic change is identified in a family, other biological relatives can choose to undergo testing themselves to better understand their cancer risk. The uptake of genetic testing in other biological relatives once a genetic condition is identified is about 20% to 30%. The Cascade Genetic Testing Platform is a virtual tool that seeks to overcome barriers related to logistics of family communication and improve dissemination of genetic testing information which is clinically actionable for individuals at highest risk for cancer. Using the Cascade Genetic Testing Platform may improve ways to share information about hereditary risk with biological relatives.
CONDITIONS
Official Title
Navigation Interventions to Improve Cascade Genetic Testing Among Relatives of Patients With Hereditary Cancer Syndromes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Probands must have a clinically confirmed autosomal dominant pathogenic germline variant associated with a hereditary cancer syndrome
- Probands must have been previously evaluated by the University of Michigan Cancer Genetics Clinic
- Probands must be 18 years or older
- Probands must be able to speak and read English
- Probands must have access to the internet
- Relatives must be biological relatives of probands
- Relatives must be 18 years or older
- Relatives must be able to speak and read English
- Relatives must have access to the internet
- Relatives must not have completed germline genetic testing according to self-report at baseline
You will not qualify if you...
- Relatives who have had prior clinical germline genetic testing for cancer or already have an upcoming appointment with a genetics provider according to self-report at baseline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
Research Team
M
MiGHT HelpLine
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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