Actively Recruiting
Navigation, Outcomes and Quality-of-life in Prostate Cancer Patients Undergoing PSMA-targeted Surgery
Led by Martini-Klinik am UKE GmbH · Updated on 2026-01-12
102
Participants Needed
2
Research Sites
149 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
As part of a feasibility study, it's planned to use a 3D virtual mixed reality model with prostate cancer patients who show signs of lymph node metastasis and are scheduled for surgery. The model is based on PSMA PET imaging performed prior to surgery and will be evaluated by surgeons, the surgical team, and patients as part of the consultation process. First, the researcher investigates whether the removal of lymph node metastases has improved compared to the data in the literature . In addition, the study examines how the 3D model influences the movement of surgical instruments and the efficiency of surgical removal of lymph node metastases. To this end, the analyzed recorded video and position data of the instruments used during procedures performed with a surgical robot. It's also an aim to develop two methods-using landmarks and visual position tracking-for more targeted navigation during surgery. Additionally, short-term results examine, such as PSA response rates, as an indication of successful lymph node metastasis removal and patient quality of life.
CONDITIONS
Official Title
Navigation, Outcomes and Quality-of-life in Prostate Cancer Patients Undergoing PSMA-targeted Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients aged 18 to 78 years
- Patients with hormone-sensitive prostate cancer scheduled for radical prostatectomy with pelvic lymph node dissection (Cohort A)
- Fewer than 3 PSMA-PET-avid lymph node metastases (PSMA expression score greater than 2) in the pelvis (Cohorts A and B)
- Patients with hormone-sensitive recurrent prostate cancer after radical prostatectomy with planned pelvic salvage lymph node dissection (Cohort B)
- PSA value less than 2 ng/ml (Cohort B)
You will not qualify if you...
- Estimated life expectancy less than 10 years
- Contraindication for surgical intervention
- Androgen deprivation therapy (ADT) within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Martini-Klinik
Hamburg, Free and Hanseatic City of Hamburg, Germany, 20246
Actively Recruiting
2
Anke Renter
Hamburg, Free and Hanseatic City of Hamburg, Germany, 25479
Not Yet Recruiting
Research Team
T
Tobias Maurer, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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