Actively Recruiting
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
Led by University of Nottingham · Updated on 2025-05-29
240
Participants Needed
1
Research Sites
219 weeks
Total Duration
On this page
Sponsors
U
University of Nottingham
Lead Sponsor
N
Nottingham University Hospitals NHS Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the comparisons of inflammatory markers between IBD and non-IBD (control) participants. The main question it aims to answer is: Are there differences in inflammatory markers between IBD and non-IBD (control) participants.
CONDITIONS
Official Title
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent before any study procedures
- Age 16 years or older
- For Crohn's disease patients: active disease defined by CRP ≥ 5 mg/L, FCP ≥ 250 µg/g, visible ulcerations with SES-CD ≥ 7 (or ≥ 4 if limited to terminal ileum), or active disease on imaging, and switching to anti-TNF therapy, ustekinumab, or upadacitinib
- For Ulcerative Colitis patients: active disease defined by CRP ≥ 5 mg/L, FCP ≥ 250 µg/g, or Mayo endoscopy subscore ≥ 2, and switching to anti-TNF alpha therapy or vedolizumab
- Non-IBD participants attending for lower GI colonoscopy with no pathology found on examination
You will not qualify if you...
- Unable to give informed consent
- Positive screening for hepatitis B surface antigen, hepatitis C, or HIV
- Ongoing infection requiring treatment
- Active COVID infection by clinical or standard care evidence
- Participation in a pharmacological clinical study within 3 months prior to baseline
- Current cancer diagnosis
- History of solid organ or stem cell transplant
- Blood, plasma, or platelet transfusion within 120 days before enrollment
- Confirmed pregnancy at enrollment
- For non-IBD participants: prior history of any form of IBD
- Investigator judgment that participation is not appropriate
- Under 16 years of age
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Nottingham
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
Actively Recruiting
Research Team
G
Gordon Moran Professor
CONTACT
N
Nadia Frowd
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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