Actively Recruiting
NC Testing in LC & POTS
Led by University of Calgary · Updated on 2026-05-07
100
Participants Needed
1
Research Sites
327 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).
CONDITIONS
Official Title
NC Testing in LC & POTS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with Long COVID
- Positive SARS-COV2 test
- Symptoms lasting more than 12 weeks after COVID
- Subjective complaint of brain fog or cognitive dysfunction
- Patients diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
- Subjective complaint of brain fog or cognitive impairment
- Healthy participants without POTS or brain fog
- Age between 18 and 60 years
- Both female and male participants
- Able to give informed consent
You will not qualify if you...
- Patients with clear causes for POTS such as dehydration or prolonged bed rest
- Inability to safely stop medications that could interfere with test results
- Any other reason the investigator believes would prevent completing the study, including poor compliance or unpredictable schedule
- Unable to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Calgary
Calgary, Alberta, Canada, T2N 4Z6
Actively Recruiting
Research Team
S
Satish R Raj, MD MSCI
CONTACT
R
Rasha Hamzeh, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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