Actively Recruiting
NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria
Led by University Hospital, Basel, Switzerland · Updated on 2025-03-04
8000
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Basel, Switzerland
Lead Sponsor
S
Swiss National Science Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an explorative, mono-center study including prospectively collected patient samples from the University Hospital of Basel. It is to investigate antimicrobial resistance (AMR) including three clinical manifestations of infectious diseases: urinary tract infection, pneumonia and deep-seated infections. The focus is on four bacteria (E. coli, Klebsiella species, S. aureus, P. aeruginosa) that are part of the high priority list of World Health Organization (WHO). Residual patient samples are analysed for proteomic, metabolomic and transcriptomic analysis, immunocytochemical or fluorescence in-situ hybridisation (FISH) analysis, flow cytometry analysis (FACS) and immunophenotyping and exploration of bacterial properties.
CONDITIONS
Official Title
NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with confirmed urinary tract infection, pneumonia (including lung transplant or cystic fibrosis patients), or deep-seated infection caused by E. coli, Klebsiella species, S. aureus, or P. aeruginosa
- Controls with no detectable bacteria in routine microbiology and no infection site at sample inclusion with 10-day follow-up and signed general consent
- Clinical controls without samples but with confirmed urinary tract infection, pneumonia, or deep-seated infection caused by E. coli, Klebsiella species, S. aureus, or P. aeruginosa
You will not qualify if you...
- Patients who have refused research reuse of their data or samples (e.g., declined general consent or other refusals)
- Patients with infections caused by bacteria other than the focus pathogens in routine microbiology
- Patients younger than 18 years
- Controls without signed general consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
Research Team
N
Nina Khanna, Prof.
CONTACT
C
Christoph Dehio, Prof.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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