NCWS or IBS/FD in Relatives of Celiac Disease Patients A Study Evaluating Symptom Prevalence and Wheat-Free Diet Effects

What this Trial Is About

Researchers are investigating the prevalence of non-celiac wheat sensitivity (NCWS) and irritable bowel syndrome/functional dyspepsia (IBS/FD) not related to wheat ingestion among relatives of patients with celiac disease (CD). This study aims to identify a subgroup of NCWS patients whose features are closer to CD than to IBS/FD, particularly among CD patients' relatives. The goal is to improve early diagnosis and understanding of these conditions, which may help reduce healthcare costs and improve quality of life for affected individuals. The study involves two main phases: first, relatives of CD patients over 18 years old who report IBS/FD-like and extraintestinal symptoms will complete questionnaires and undergo screenings including HLA typing and CD serology. Those suspected of having CD will receive a duodenal biopsy. In the second phase, identified patients will follow a strict six-week wheat-free diet (WFD) under dietician supervision. After the diet, symptom changes will be assessed to distinguish between self-reported NCWS and IBS/FD not related to wheat intake. Participants will provide information through online questionnaires covering demographics, symptoms, and quality of life at multiple time points. Clinical assessments include serological tests, HLA typing, and biopsies when indicated. Researchers will monitor adherence to the wheat-free diet and measure symptom changes using validated rating scales over six weeks. The primary outcome is the identification of patients with self-reported NCWS or IBS/FD not related to wheat intake using the Gastrointestinal Symptom Rating Scale (GSRS) from baseline to six weeks.

NCWS or IBS/FD in Relatives of CD Patients