Actively Recruiting
Near Fatal Asthma in Children and Young People
Led by University of Edinburgh · Updated on 2025-06-27
400
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will report the frequency, risks factors, clinical care and estimate the future asthma risk of children and young people (aged 5-15 years) experiencing a Delphi defined near fatal asthma (NFA) attacks in the United Kingdom (UK) and Republic of Ireland (ROI). A greater understanding of the frequency and risk factors associated with NFA could help support children and young people (CYP), parents and clinicians to identify and modify risk, both independently and through a resulting clinical care pathway and also develop future research to improve effectiveness of interventions. The study will explore both commonly identified clinical factors, but also for the first time describe in detail the variance in medical management (acute and intensive care) that could lead to future clinical trials and guideline development to standardise care. The study will also describe, through data-linkage, socio-demographic factors associated with NFA, to include pollution, pollen, weather, viral prevalence that could lead to better care for higher risk CYP. To encourage more consistent, less fragmented care following a near fatal asthma attack, the study will consider how care is provided subsequent to an NFA attack using British Paediatric Surveillance Unit (BPSU) surveillance at 12 and 24 month follow up.
CONDITIONS
Official Title
Near Fatal Asthma in Children and Young People
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Child or young person aged 5 to 15 years
- Experienced an acute episode of near fatal asthma as defined by Delphi criteria
- Survived to hospital discharge after the asthma episode
- Meets at least one of the following during the acute episode: severe breathing difficulty with pulse oxygen saturation below 92% despite maximal oxygen therapy, pH ≤ 7.2 and/or pCO2 ≥ 60mmHg or 8kPa, use of intravenous bronchodilator infusion
- Had a respiratory arrest and/or required cardiopulmonary resuscitation
- Was invasively ventilated during the asthma episode
You will not qualify if you...
- Children and young people not meeting the case definition of near fatal asthma
- Borderline cases will be excluded after review by an expert panel of three clinicians
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Edinburgh
Edinburgh, United Kingdom
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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