Actively Recruiting
Neoadjuvant vs Adjuvant in Locally Advanced Recurrent NPC
Led by Eye & ENT Hospital of Fudan University · Updated on 2025-06-03
154
Participants Needed
7
Research Sites
155 weeks
Total Duration
On this page
Sponsors
E
Eye & ENT Hospital of Fudan University
Lead Sponsor
S
Shanghai Zhongshan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
A multicenter randomized controlled study of surgery combined with neoadjuvant and adjuvant therapy for locally advanced recurrent nasopharyngeal carcinoma in comparison to surgery combined with adjuvant therapy
CONDITIONS
Official Title
Neoadjuvant vs Adjuvant in Locally Advanced Recurrent NPC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with recurrent nasopharyngeal carcinoma confirmed by pathology
- Disease staging rT2, rT3, or rT4 according to AJCC 8th edition
- Cervical lymph node metastasis controllable locally
- Aged between 18 and 75 years
- Signed informed consent to participate in the trial
- No distant metastasis
- At least 6 months since completing radical radiation therapy before recurrence
- Only one previous course of radiotherapy received
- Sufficient organ function
- ECOG performance status score between 0 and 2, able to tolerate surgery, chemotherapy, and immunotherapy
You will not qualify if you...
- Currently participating in other interventional clinical trials
- Having uncontrolled illnesses that could interfere with the therapy
- Diagnosed with another or multiple cancers within the last 5 years (except fully treated basal cell or skin squamous cell carcinoma, cervical carcinoma in situ, etc.)
- Any contraindication to surgery
- Having serious autoimmune disease
- Using immunosuppressive agents or systemic hormone therapy (more than 10 mg/day prednisone or equivalent) within 2 weeks prior to first treatment
- Experiencing severe allergic reactions to monoclonal antibodies
- History of radioactive particle implantation
- Received live vaccine within 4 weeks before starting the study or during the study
- Female who is pregnant or breastfeeding
- Other conditions judged by researchers to make participation unsuitable
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 7 locations
1
Eye& ENT Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200031
Actively Recruiting
2
Fujian Medical University Union Hospital
Fuzhou, China
Not Yet Recruiting
3
The People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, China
Actively Recruiting
4
Changhai Hospital
Shanghai, China
Not Yet Recruiting
5
Shanghai Sixth People's Hospital
Shanghai, China
Not Yet Recruiting
6
Shanghai Zhongshan Hospital
Shanghai, China
Not Yet Recruiting
7
Shenzhen Second People's Hospital
Shenzhen, China
Not Yet Recruiting
Research Team
X
Xiaole Song
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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