Actively Recruiting
Neoadjuvant Chemoradiotherapy Compared to Neoadjuvant Chemotherapy for Luminal-Type Locally Advanced Breast Cancer: A Clinical Study
Led by Sichuan Cancer Hospital and Research Institute · Updated on 2024-11-20
148
Participants Needed
1
Research Sites
140 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study focuses on preoperative treatment modalities for luminal-type locally advanced breast cancer. Based on modern precision radiotherapy technologies such as MRI-Linac, CyberKnife, and VMAT, it aims to compare the pCR rate, breast conserving surgery (BCS) rate, progression-free survival (PFS), and treatment-related side effects between preoperative neoadjuvant chemotherapy and preoperative neoadjuvant SBRT combined with chemotherapy in patients with this type of breast cancer. The goal is to provide new strategic options for the preoperative treatment of luminal-type locally advanced breast cancer.
CONDITIONS
Official Title
Neoadjuvant Chemoradiotherapy Compared to Neoadjuvant Chemotherapy for Luminal-Type Locally Advanced Breast Cancer: A Clinical Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed invasive breast cancer
- Breast MRI showing stage IIB to IIIC according to 2017 AJCC 8th edition
- Clinical staging including chest MRI and/or axillary ultrasound, CT scans of neck, abdomen, pelvis, and bone scans
- Karnofsky performance score of 80 or higher, or ECOG performance status of 0 to 1
- No history of allergy to doxorubicin, cyclophosphamide, paclitaxel, or docetaxel
- No prior treatment with radiotherapy, chemotherapy, endocrine therapy, targeted therapy, or immunotherapy
You will not qualify if you...
- History of other malignancies except curable non-melanoma skin cancer and cervical carcinoma in situ
- Inability to complete MRI
- Diagnosis of inflammatory breast cancer
- Presence of bilateral or multifocal primary tumors
- Active infection
- Clinically evident heart disease
- Myocardial infarction or stroke within 6 months before enrollment
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sichuan Cancer Hospital
Chengdu, Sichuan, China, 610041
Actively Recruiting
Research Team
Q
Qian Peng, Phd
CONTACT
R
Rui Li, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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