Actively Recruiting
Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma
Led by Eye & ENT Hospital of Fudan University · Updated on 2025-12-23
116
Participants Needed
7
Research Sites
209 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multi-center, randomized controlled, prospective clinical study.
CONDITIONS
Official Title
Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willingness to provide written informed consent
- Age 18 to 75 years
- No prior treatment for malignant disease
- Resectable stage III-IVA hypopharyngeal carcinoma with at least 50% response after neoadjuvant therapy according to RECIST 1.1
- ECOG performance status between 0 and 2
You will not qualify if you...
- Pregnancy or breastfeeding
- Allergy to sintilimab, nab-paclitaxel, or their components
- Poorly controlled heart conditions or other serious diseases
- Active or history of autoimmune diseases requiring systemic treatment
- Presence of other simultaneous or previous cancers
- Any other condition making participation unsafe or unsuitable as judged by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
Not Yet Recruiting
2
Shandong Provincial ENT Hospital
Jinan, Shandong, China
Not Yet Recruiting
3
Beijing Tongren Hospital, Capital Medical University
Beijing, China
Not Yet Recruiting
4
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, China
Not Yet Recruiting
5
Eye & ENT Hospital, Fudan University
Shanghai, China
Actively Recruiting
6
Zhongshan Hospital of Fudan University
Shanghai, China
Not Yet Recruiting
7
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Not Yet Recruiting
Research Team
C
Chiyao Hsueh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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