Actively Recruiting
Neoadjuvant Chemotherapy for Locally Advanced Gall Bladder Cancer : a Randomized Control Trial (NEOGB)
Led by Rajiv Gandhi Cancer Institute & Research Center, India · Updated on 2025-04-16
114
Participants Needed
3
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
to study role of chemotherapy treatment for gall bladder cancer before surgery as compared to surgery directly
CONDITIONS
Official Title
Neoadjuvant Chemotherapy for Locally Advanced Gall Bladder Cancer : a Randomized Control Trial (NEOGB)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ECOG performance status 0 to 2
- Locally advanced resectable gallbladder cancer defined as clinical T3 or T4 disease or regional lymph node involvement on imaging
- Post cholecystectomy gallbladder cancer with residual disease on imaging, history of bile spillage during initial surgery, or piece-meal gallbladder removal during simple cholecystectomy with regional lymph node involvement on imaging
You will not qualify if you...
- Early gallbladder cancer (cT1 or cT2) without significant lymphadenopathy or liver infiltration on imaging
- Locally advanced disease requiring major hepatectomy or Whipple's pancreatoduodenectomy
- Post cholecystectomy gallbladder cancer without evidence of spillage or residual disease on imaging
- Obstructive jaundice due to tumor involvement of the biliary tree
- Vascular involvement such as common hepatic artery, main portal vein, right hepatic artery, or right portal vein
- Any distant metastasis or isolated port site metastasis
- Involvement of non-regional lymph nodes (e.g., celiac, superior mesenteric artery, inter-aortocaval, or left para-aortic lymph nodes)
- Poor performance status with ECOG 3 or higher
- Pregnancy
- Inability or unwillingness to follow the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Rajiv Gandhi Cancer Institute and Research Centre
Delhi, National Capital Territory of Delhi, India, 110085
Actively Recruiting
2
Rajiv Gandhi Cancer Institute and Research Centre
Delhi, National Capital Territory of Delhi, India, 110085
Actively Recruiting
3
Rajiv Gandhi Cancer Institute and Research Centre
Delhi, National Capital Territory of Delhi, India, 110085
Actively Recruiting
Research Team
S
Shivendra Singh, Mch
CONTACT
S
Shaifali Goel, DrNB
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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