Actively Recruiting
Neoadjuvant Darovasertib in Primary Uveal Melanoma
Led by IDEAYA Biosciences · Updated on 2026-05-06
520
Participants Needed
94
Research Sites
265 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)
CONDITIONS
Official Title
Neoadjuvant Darovasertib in Primary Uveal Melanoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary non-metastatic uveal melanoma
- Able and willing to provide written, informed consent
- ECOG performance status of 0 or 1
- Adequate organ function
You will not qualify if you...
- Previous treatment for uveal melanoma
- Evidence of metastatic uveal melanoma
- Conditions requiring enucleation regardless of therapy response
- Progressive secondary eye disease affecting vision assessments
- Presence of other malignant diseases besides the one studied
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 94 locations
1
Mayo Clinic Scottsdale - PPDS
Scottsdale, Arizona, United States, 85259
Actively Recruiting
2
UCSD Moores Cancer Center
La Jolla, California, United States, 92093
Not Yet Recruiting
3
Jules Stein Eye Institute
Los Angeles, California, United States, 90024
Not Yet Recruiting
4
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Not Yet Recruiting
5
University of California Irvine Medical Center
Orange, California, United States, 92868
Not Yet Recruiting
6
Stanford Comprehensive Cancer Center
Palo Alto, California, United States, 94304
Actively Recruiting
7
Kaiser Permanente-Riverside Medical Center
Riverside, California, United States, 92505-3043
Actively Recruiting
8
UCSF Wayne and Gladys Valley Center for Vision
San Francisco, California, United States, 94143
Not Yet Recruiting
9
University of Colorado Hospital
Aurora, Colorado, United States, 80045
Actively Recruiting
10
The Melanoma and Skin Cancer Institute
Englewood, Colorado, United States, 80113-2791
Not Yet Recruiting
11
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32224
Actively Recruiting
12
USF Health Eye Institute
Tampa, Florida, United States, 33612-6601
Not Yet Recruiting
13
Moffit Cancer Center
Tampa, Florida, United States, 33612
Not Yet Recruiting
14
Wilmer Eye Institute
Baltimore, Maryland, United States, 21287-0005
Actively Recruiting
15
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Not Yet Recruiting
16
W Kellogg Eye Center
Ann Arbor, Michigan, United States, 48105
Not Yet Recruiting
17
The Cancer and Hematology Centers of West Michigan (CHCWM)
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
18
Mayo Clinic - PPDS
Rochester, Minnesota, United States, 55905
Actively Recruiting
19
TIERING Percentiles
Omaha, Nebraska, United States, 68105
Not Yet Recruiting
20
Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
Actively Recruiting
21
Memorial Sloan Kettering Cancer Center - 1275 York Ave
New York, New York, United States, 10065-6635
Not Yet Recruiting
22
Northwell Health Cancer Institute
New York, New York, United States, 11042
Not Yet Recruiting
23
Cole Eye Institute-9500 Euclid Ave
Cleveland, Ohio, United States, 44195
Not Yet Recruiting
24
Ohio State Eye and Ear Institute
Columbus, Ohio, United States, 43212
Not Yet Recruiting
25
Retina Consultants of Oklahoma
Oklahoma City, Oklahoma, United States, 73112
Not Yet Recruiting
26
Jefferson Health Honickman Center
Philadelphia, Pennsylvania, United States, 19107
Not Yet Recruiting
27
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Not Yet Recruiting
28
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
29
Vanderbilt Eye Institute
Nashville, Tennessee, United States, 37232
Not Yet Recruiting
30
Austin Retina Associates - Central
Austin, Texas, United States, 78705
Actively Recruiting
31
Texas Retina Associates - Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
32
University of Texas Southwestern Medical Center-5323 Harry Hines Blvd
Dallas, Texas, United States, 75390-9057
Actively Recruiting
33
Retina Consultants of Texas - (Houston)
Houston, Texas, United States, 77030-2727
Not Yet Recruiting
34
Augusta Health, Center for Cancer and Blood Disorders
Fishersville, Virginia, United States, 22939
Not Yet Recruiting
35
University of Wisconsin Health
Madison, Wisconsin, United States, 53705-3644
Not Yet Recruiting
36
Gallipoli Medical Research Foundation
Greenslopes, Queensland, Australia, QLD 4120
Not Yet Recruiting
37
The Queen Elizabeth Hospital
Woodville South, South Australia, Australia, 5011
Not Yet Recruiting
38
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Not Yet Recruiting
39
The Crown Princess Mary Cancer Centre (Westmead Hospital), NSW 214
Westmead, Australia, NSW 2145
Not Yet Recruiting
40
LKH-Universitätsklinikum Graz
Graz, Austria, 8036
Not Yet Recruiting
41
Universitätsklinikum Innsbruck
Innsbruck, Austria, 6020
Not Yet Recruiting
42
Universitätsklinikum AKH Wien
Vienna, Austria, 1090
Not Yet Recruiting
43
Cliniques Universitaires Saint-Luc - PPDS
Brussels, Belgium, 1200
Actively Recruiting
44
UZ Leuven - PPDS
Leuven, Belgium, 3000
Not Yet Recruiting
45
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Not Yet Recruiting
46
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
47
Ustredni vojenska nemocnice - Vojenska fakultni nemocnice Praha
Prague, Prague, Czechia, 169 02
Actively Recruiting
48
Rigshospitalet
Copenhagen O, Capital, Denmark, 2100
Not Yet Recruiting
49
Aarhus Universitetshospital
Aarhus, Central Jutland, Denmark, 8200
Not Yet Recruiting
50
East Tallinn Central Hospital-Pärnu road 104
Tallinn, Harju, Estonia, 11312
Not Yet Recruiting
51
CHU de Nice-Hôpital Pasteur
Nice, Alpes-Maritimes, France, 6000
Not Yet Recruiting
52
Centre Retine Gallien - Bordeaux
Bordeaux, Gironde, France, 33000
Not Yet Recruiting
53
CHU de Rennes - Hôpital Pontchaillou
Rennes, Ille-et-Vilaine, France, 35000
Not Yet Recruiting
54
Institut Curie - Hôpital de Paris
Paris, Paris, France, 75248
Not Yet Recruiting
55
Centre Hospitalier National D'ophtalmologie Des Quinze Vingts
Paris, France, 75571
Not Yet Recruiting
56
Universitätsklinikum Tübingen
Tübingen, Baden-Wurttemberg, Germany, 72076
Not Yet Recruiting
57
Universitätsklinikum Ulm
Ulm, Baden-Wurttemberg, Germany, 89075
Not Yet Recruiting
58
Hautklinik Erlangen
Erlangen, Bavaria, Germany, 91054
Not Yet Recruiting
59
Universitätsklinikum Essen
Essen, North Rhine-Westphalia, Germany, 45147
Not Yet Recruiting
60
Städtisches Klinikum Dessau
Dessau, Saxony-Anhalt, Germany, 6847
Not Yet Recruiting
61
Charité - Universitätsmedizin Berlin
Berlin, Germany, 12203
Not Yet Recruiting
62
Universitätsklinikum Bonn
Bonn, Germany, 53127
Not Yet Recruiting
63
Universitätsklinikum Schleswig-Holstein - Campus Lübeck
Lübeck, Germany, 23562
Not Yet Recruiting
64
Universitätsklinikum Giessen und Marburg - Marburg (UKGM)
Marburg, Germany, 35043
Not Yet Recruiting
65
Universitätsklinikum Würzburg
Würzburg, Germany, 97080
Not Yet Recruiting
66
PAGNI-University General Hospital of Heraklion
Heraklion, Irakleio, Greece, 715 00
Not Yet Recruiting
67
University General Hospital of Larissa
Larissa, Larissa, Greece, 41 110
Not Yet Recruiting
68
AHEPA University General Hospital of Thessaloniki
Thessaloniki, Thessaloníki, Greece, 546 36
Not Yet Recruiting
69
The Chaim Sheba Medical Center - PPDS
Ramat Gan, Central District, Israel, 5262100
Actively Recruiting
70
Hadassah Medical Center - PPDS
Jerusalem, Jerusalem, Israel, 91120
Actively Recruiting
71
Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale
Naples, Campania, Italy, 80131
Not Yet Recruiting
72
ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco
Milan, Milan, Italy, 20157
Not Yet Recruiting
73
Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia
Perugia, Perugia, Italy
Not Yet Recruiting
74
Azienda Ospedaliera Universitaria Careggi
Florence, Tuscany, Italy, 50134
Actively Recruiting
75
Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia
Pisa, Italy, 56124
Not Yet Recruiting
76
Fondazione Policlinico Universitario A Gemelli - Rome - PPDS
Rome, Italy, 168
Not Yet Recruiting
77
Erasmus MC
Rotterdam, South Holland, Netherlands, 3015 GD
Not Yet Recruiting
78
Auckland Eye
Auckland, Auckland, New Zealand, 1050
Not Yet Recruiting
79
Uniwersytecki Szpital Kliniczny w Poznaniu- Dluga 1/2
Poznan, Greater Poland Voivodeship, Poland, 61-848
Not Yet Recruiting
80
WIM-PIB, Centralny Szpital Kliniczny MON
Warsaw, Masovian Voivodeship, Poland, 04-141
Not Yet Recruiting
81
Uniwersyteckie Centrum Kliniczne w Gdansku - Debinki 7
Gdansk, Pomeranian Voivodeship, Poland, 80-214
Not Yet Recruiting
82
Fakultna nemocnica s poliklinikou F. D. Roosevelta
Banská Bystrica, Slovakia, 975 17
Not Yet Recruiting
83
Institute of Oncology Ljubljana
Ljubljana, Ljubljana, Slovenia, 1000
Not Yet Recruiting
84
Hospital Clinico Universitario de Santiago
Santiago de Compostela, A Coruña, Spain, 15706
Actively Recruiting
85
Hospital Universitario de Bellvitge
L'Hospitalet de Llobregat, Barcelona, Spain, 8907
Not Yet Recruiting
86
Clinica Universidad Navarra
Pamplona, Navarre, Spain, 31008
Actively Recruiting
87
Hospital Universitari i Politecnic La Fe de Valencia
Valencia, Valencia, Spain, 46026
Not Yet Recruiting
88
Hospital Clinico Universitario de Valladolid
Valladolid, Valladolid, Spain, 47003
Actively Recruiting
89
Hospital Universitario Virgen Macarena
Seville, Spain, 41009
Actively Recruiting
90
Universitätsspital Basel
Basel, Switzerland, 4031
Actively Recruiting
91
Universitätsspital Zürich
Zurich, Switzerland, 8091
Actively Recruiting
92
Clatterbridge Cancer Centre - Liverpool - NWCRN - PPDS
Metropolitan Borough of Wirral, Merseyside, United Kingdom, CH63 4JY
Not Yet Recruiting
93
University College Hospital
London, United Kingdom, NW1 2BU
Not Yet Recruiting
94
Weston Park Cancer Centre - PPDS
Sheffield, United Kingdom, S10 2TF
Not Yet Recruiting
Research Team
I
IDEAYA Clinical Trials
CONTACT
M
Mwe Mwe Chao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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