Actively Recruiting
Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)
Led by University of California, San Diego · Updated on 2025-06-25
29
Participants Needed
3
Research Sites
223 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The majority of head and neck cancer patients do not respond to immunotherapies, and clinical responses are often not durable. However, targeting tumors with stereotactic radiation in combination with immunotherapy while sparing draining lymphatics enhances anticancer immunity, resulting in dramatic response in HPV (Human Papilloma Virus) virus related cancers of the throat. This trial will leverage targeted tumor radiation and immunotherapy in advance of standard surgical therapy to improve the response of HPV (Human Papilloma Virus) throat cancer to radiation and immunotherapy.
CONDITIONS
Official Title
Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed diagnosis of Stage I T1-2N1M0 HPVOPC (Human Papilloma Virus Oropharynx Cancer)
- Amenable to surgical resection
- Able to safely receive neoadjuvant radiation and Evorpacept/Pembrolizumab
You will not qualify if you...
- Patients with solitary lymph nodes less than 3 cm
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
UC San Diego Moores Cancer Center
La Jolla, California, United States, 92093
Actively Recruiting
2
Providence Health & Services
Portland, Oregon, United States, 97213
Actively Recruiting
3
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
Research Team
J
Joseph A Califano, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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