Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT07396324

Neoadjuvant QL1706 in Patients With Hormone Receptor Positive, HER2-negative Breast Cancer

Led by RenJi Hospital · Updated on 2026-05-13

55

Participants Needed

1

Research Sites

291 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is an prospective, open label, multicenter study to evaluate the efficacy and safety of neoadjuvant Iparomlimab and Tuvonralimab (QL1706) in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer.

CONDITIONS

Official Title

Neoadjuvant QL1706 in Patients With Hormone Receptor Positive, HER2-negative Breast Cancer

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 6518 years
  • Histologically confirmed hormone receptor positive and HER2 negative breast cancer
  • At least one evaluable lesion
  • ECOG performance status of 0 or 1
  • Adequate organ function
Not Eligible

You will not qualify if you...

  • Metastatic disease (Stage IV)
  • Female patients who are pregnant or lactating
  • Women of childbearing potential who test positive on baseline pregnancy test
  • Women of childbearing age unwilling to use effective contraception during the trial

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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2
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Trial Site Locations

Total: 1 location

1

Renji Hospital, School of Medicine, Shanghai Jiaotong University

Shanghai, China, 200127

Actively Recruiting

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Research Team

W

Wenjin Yin

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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Neoadjuvant QL1706 in Patients With Hormone Receptor Positive, HER2-negative Breast Cancer | DecenTrialz