Actively Recruiting
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study
Led by Case Comprehensive Cancer Center · Updated on 2026-05-08
36
Participants Needed
2
Research Sites
686 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This Phase I/II trial studies the ability to stop brain metastases from coming back after treatment with radiosurgery followed by surgical resection. It will also evaluate the side effects of these combined treatments and help determine the best radiosurgery dose. Radiosurgery focuses the x-rays directly to the tumor and cause less damage to the normal tissue in the brain.
CONDITIONS
Official Title
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a prior histologic diagnosis of cancer other than small cell lung cancer, lymphoma, and germ cell histologies
- Have MRI evidence of 1 to 4 brain metastases, with at least one lesion larger than 20 mm and up to 50 mm in maximal diameter suitable for radiosurgery and complete surgical removal
- All other brain metastases must be suitable for radiosurgery
- May have had prior radiosurgery to lesions other than the one planned for neoadjuvant radiosurgery and resection
- Have a Karnofsky performance score of 70 or higher
You will not qualify if you...
- Medically unfit to undergo surgical removal of brain metastasis
- Prior whole brain radiotherapy
- Contraindication for MRI imaging
- Unable to participate due to physical or mental limitations
- Unable or unwilling to attend all required follow-up visits
- Unable to safely deliver 10 Gray or less to optic nerve/chiasm at planning
- Tumor located in the brainstem
- Imaging or cytologic evidence of leptomeningeal disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106
Withdrawn
2
Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
E
Erin Murphy, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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