Actively Recruiting
Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis
Led by University Hospital Ostrava · Updated on 2025-05-04
260
Participants Needed
4
Research Sites
191 weeks
Total Duration
On this page
Sponsors
U
University Hospital Ostrava
Lead Sponsor
U
University Hospital Olomouc
Collaborating Sponsor
AI-Summary
What this Trial Is About
This multicentre proof-of-concept study, involving 4 centers, aims to establish the value of fractionated neoadjuvant stereotactic radiotherapy (NaSRT) as a new treatment paradigm for brain metastases (BM) in the frame of the Czech neurooncology network. Most relevant studies published to date used single-fraction radiotherapy and dealt with the inherent bias related to their retrospective nature. The researchers aim to increase the level of evidence for this treatment paradigm together with other similar ongoing studies.
CONDITIONS
Official Title
Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Karnofsky Performance Status of 60 or higher
- Histologically confirmed primary cancer
- MRI showing brain metastases
- Brain metastases planned for surgical removal and other metastases suitable for radical stereotactic radiotherapy
- Brain metastases measuring between 1 cm and 7 cm on MRI with contrast
You will not qualify if you...
- Confirmed blood-related cancers
- Small-cell lung carcinoma
- Emergency condition requiring immediate brain surgery
- Previous whole-brain radiotherapy
- Previous stereotactic radiotherapy to target brain metastases
- Pregnancy
- Inability to have brain metastasis surgery within 7 days after neoadjuvant stereotactic radiotherapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
University Hospital Ostrava
Ostrava, Moravian-Silesian Region, Czechia, 70852
Actively Recruiting
2
Masaryk Memorial Cancer Institute
Brno, Czechia, 65653
Actively Recruiting
3
University Hospital Hradec Králové
Hradec Králové, Czechia, 50005
Actively Recruiting
4
University Hospital Olomouc
Olomouc, Czechia, 77900
Actively Recruiting
Research Team
J
Jiří Hynčica
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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