Actively Recruiting
Neoadjuvant Treatment With Atezolizumab and Atezolizumab as Maintenance for the Treatment of Stage III Non Small-Cell Lung Cancer (NSCLC)
Led by Fundación GECP · Updated on 2025-11-19
97
Participants Needed
21
Research Sites
512 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an open-label, phase II, multi-centre clinical trial. 97 Patients with stage IIIA and IIIB non-small cell lung cancer will be enrolled. The treatment is Atezolizumab + Paclitaxel + Carboplatin 3 cycles as neoadjuvant/induction treatment. After the induction treatment every patient will be evaluated by a multidisciplinary team in each participant hospital to decide if the patient is candidate for surgery or not. Depending on the decision each patient will be treated in a different way. The primary objective is to evaluate the Progression free survival (PFS). The total trial duration will be 10 years approximately. Patient accrual is expected to be completed within 2 years. Two years of treatment, 5 years of follow up, and 4-6 months of close-out.
CONDITIONS
Official Title
Neoadjuvant Treatment With Atezolizumab and Atezolizumab as Maintenance for the Treatment of Stage III Non Small-Cell Lung Cancer (NSCLC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Previously untreated patients with stage IIIA or IIIB non-small cell lung cancer confirmed by biopsy
- No distant spread of the cancer
- Performance status of 0 or 1 on the ECOG scale
- Adequate blood counts and organ function
- Signed informed consent according to guidelines
- Adequate lung function
- Age over 18 years
- Agreement to use highly effective contraception if of childbearing potential
- Negative pregnancy test for women not postmenopausal or surgically sterile
- Ability to comply with treatment and follow-up requirements
You will not qualify if you...
- Presence of mutations in the EGFR gene or ALK fusion oncogene
- Known STK-11 ligand alterations, MDM2 amplifications, or ROS1 translocations
- Weight loss greater than 10% in the last 3 months
- Previous treatment with anti-cancer drugs, chest radiotherapy, or lung cancer surgery
- Other cancers within 3 years before enrollment
- Pleural or pericardial fluid buildup
- Allergy to atezolizumab
- History of autoimmune or lung diseases
- Positive test for HIV
- Active hepatitis B or C infection
- Active tuberculosis
- Symptomatic neuropathy grade higher than 1
- Severe infections within 4 weeks before study entry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 21 locations
1
Hospital General Universitario Dr. Balmis de Alicante
Alicante, Alicante, Spain, 03010
Actively Recruiting
2
ICO Badalona, Hospital Germans Trias i Pujol
Badalona, Barcelona, Spain, 08916
Actively Recruiting
3
Hospital Universitari Vall d' Hebron
Barcelona, Barcelona, Spain, 08035
Actively Recruiting
4
Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain, 08041
Actively Recruiting
5
Hospital Parc Taulí
Barcelona, Barcelona, Spain, 08208
Actively Recruiting
6
Hospital De Basurto
Bilbao, Bilbao, Spain, 48013
Actively Recruiting
7
Hospital Univ. De Jerez De La Frontera
Jerez de la Frontera, Cadiz, Spain, 11407
Actively Recruiting
8
ICO Girona, Hospital Josep Trueta
Girona, Girona, Spain, 17007
Actively Recruiting
9
Hospital Universitario Clinico San Cecilio
Granada, Granada, Spain, 18007
Actively Recruiting
10
Hospitalario Universitario A Coruña
A Coruña, La Coruña, Spain, 15006
Actively Recruiting
11
Hospital Universitari de Gran Canària Doctor Negrín
Las Palmas de Gran Canaria, Las Palmas, Spain, 35010
Actively Recruiting
12
Hospital Universitario Lucus Augusti
Lugo, Lugo, Spain, 27003
Actively Recruiting
13
Hospital Universitario Fundación Jiménez Díaz
Madrid, Madrid, Spain, 28040
Not Yet Recruiting
14
Hospital Universitario Puerta de Hierro
Majadahonda, Madrid, Spain, 28222
Actively Recruiting
15
Hospital Universitari Son Llatzer
Palma de Mallorca, Palma de Mallorca, Spain, 07198
Actively Recruiting
16
Complejo Hospitalario de Navarra
Pamplona, Pamplona, Spain, 31008
Actively Recruiting
17
Hospital Universitario Salamanca
Salamanca, Salamanca, Spain, 37007
Actively Recruiting
18
Hospital Universitario Nuestra Señora La Candelaria
Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain, 38009
Actively Recruiting
19
Hospital Universitario Virgen Del Rocio
Seville, Sevilla, Spain, 41013
Actively Recruiting
20
Hospital Universitari Sant Joan de Reus
Reus, Tarragona, Spain, 43204
Actively Recruiting
21
Hospital General Universitario de Valencia
Valencia, Valencia, Spain, 46014
Actively Recruiting
Research Team
E
Eva Pereira
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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