Actively Recruiting
Neocortical Microarchitecture of Executive Function
Led by University of Colorado, Denver · Updated on 2025-09-17
15
Participants Needed
1
Research Sites
122 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.
CONDITIONS
Official Title
Neocortical Microarchitecture of Executive Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Parkinson's disease and refractory to medications requiring deep brain stimulation
- Aged 45-85 years
- Able to provide informed consent
- Normal neuropsychiatric evaluation showing no greater than mild impairments in executive function
- Medically able to undergo deep brain stimulation surgery as evaluated by study neurosurgeon
- Surgical plan includes safe entry point in dorsal lateral prefrontal cortex
- Able to tolerate awake deep brain stimulation surgery with plan for it to be done awake
- Able to tolerate 25 additional minutes of awake surgery
- Able to participate and comply with tasks with instructions provided in English
You will not qualify if you...
- Moderate or severe cognitive impairment determined by licensed neuropsychologist
- Inability to tolerate awake surgery as determined by neurologist and study neurosurgeon
- Unsafe access to dorsal lateral prefrontal cortex for electrode placement
- Moderate or severe executive function deficits based on neuropsychological testing
- Clinically significant abnormalities on preoperative imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
P
Pamela David Gerecht, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DEVICE_FEASIBILITY
Number of Arms
1
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