Neonatal Data and Biobank to Study Factors Influencing Development in Preterm Infants Born Before 32 Weeks' Gestation and/or Under 1500 g Birth Weight

What this Trial Is About

Researchers are investigating factors that influence the development and long-term health outcomes of very preterm infants born before 32 weeks of gestation and/or with a birth weight under 1500 grams. The study aims to understand risks and protective factors affecting multiple organ systems such as neurological, pulmonary, cardiovascular, and renal systems. It also seeks to improve knowledge about survival and quality of life for these infants through a comprehensive, prospective data collection and biobank. The study involves collecting detailed clinical information and biological samples from preterm infants receiving care at the University Hospital Cologne's perinatal center. Participants are followed within a standardized, interdisciplinary program that monitors their development over several years. This approach allows for the collection of data on growth, neurocognitive function, and other health outcomes, alongside biological markers like gene expression and cytokine profiles. Parents or legal guardians provide consent for participation, and infants are tracked through routine follow-up visits that assess survival without impairments in cognition, motor skills, vision, hearing, or seizures up to five years of age. Secondary outcomes include breastfeeding duration, growth measurements, maternal mental health, parental bonding, and social support. This long-term observation aims to identify biomarkers and clinical factors to better predict risks and guide future preventive or therapeutic care for preterm infants.

Neonatal Data and Biobank to Study Factors Influencing Development in Preterm Infants Born at <32 Weeks' Gestation and/or <1500 g Birth Weight