Actively Recruiting
Neonatal Platelet Transfusion Threshold Trial
Led by NICHD Neonatal Research Network · Updated on 2026-03-25
2433
Participants Needed
20
Research Sites
306 weeks
Total Duration
On this page
Sponsors
N
NICHD Neonatal Research Network
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of the NeoPlaTT trial is to test whether, among extremely preterm infants born at 23 0/7 to 26 6/7 weeks' gestation, a lower platelet transfusion threshold, compared to a higher threshold, improves survival without major or severe bleeding up to 40 0/7 weeks' postmenstrual age (PMA).
CONDITIONS
Official Title
Neonatal Platelet Transfusion Threshold Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Gestational age of 23 0/7 to 26 6/7 weeks
- Postnatal age less than 48 hours
You will not qualify if you...
- Comfort care or withdrawal of care planned
- Neonatal alloimmune thrombocytopenia or suspected/confirmed congenital platelet or bleeding disorder
- Receipt of platelet transfusion
- No receipt of Vitamin K
- Parents/guardian decline consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 20 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
3
Sharp Mary Birch Hospital for Women & Newborns
San Diego, California, United States, 92123
Actively Recruiting
4
University of Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
5
Emory University
Atlanta, Georgia, United States, 30303
Actively Recruiting
6
Northwestern Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
7
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
8
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
9
University of New Mexico
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
10
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
11
Duke University
Durham, North Carolina, United States, 27710
Actively Recruiting
12
Cincinnati Children's Medical Center
Cincinnati, Ohio, United States, 45267
Actively Recruiting
13
Case Western Reserve University, Rainbow Babies and Children's Hospital
Cleveland, Ohio, United States, 44106
Actively Recruiting
14
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
15
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
16
Vanderbilt University
Nashville, Tennessee, United States, 37232
Actively Recruiting
17
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75235
Actively Recruiting
18
University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
19
Pediatrix Medical Group
San Antonio, Texas, United States, 78229
Actively Recruiting
20
University of Utah
Salt Lake City, Utah, United States, 84108
Actively Recruiting
Research Team
R
Ravi M Patel, MD
CONTACT
A
Abhik Das, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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