Neonatologist-performed Lung Ultrasound to Guide Respiratory Therapy and Prevent Extubation Failure in Term and Preterm Neonates - A Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating the use of lung ultrasound performed by neonatologists (NPLUS) to guide respiratory therapy and prevent extubation failure in newborns who have been on invasive mechanical ventilation. The study focuses on both preterm and full-term neonates and aims to assess how accurately NPLUS can detect lung issues after extubation and whether it helps prompt earlier interventions to avoid respiratory failure. The intervention involves conducting lung ultrasound scans using a high-frequency linear transducer probe while the neonate lies in a supine position. The scan covers six lung areas sequentially, and lung ultrasound scores are recorded at three specific time points after extubation. The ultrasound videos are reviewed by two independent neonatologists to ensure reliability. This approach helps assess lung aeration and identifies early signs of lung collapse or atelectasis, which may guide timely respiratory therapy adjustments. Participants will undergo lung ultrasounds at designated times after extubation to monitor lung condition. The main outcome measured is the rate of reintubation within 72 hours after extubation. Researchers will also observe whether early lung ultrasound findings lead to interventions that prevent clinical deterioration. The study involves careful monitoring of lung function and respiratory support needs during this critical period following weaning from mechanical ventilation.

Neonatologist-performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy to Prevent Extubation Failure