Actively Recruiting
NeoRad Breast Cancer Study
Led by Bielefeld University · Updated on 2025-05-07
1826
Participants Needed
16
Research Sites
530 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The NEORAD trial tests whether preoperative radiotherapy results in an improved DFS and less radiation induced late effect compared to postoperative radiotherapy in higher risk breast cancer after NACT.
CONDITIONS
Official Title
NeoRad Breast Cancer Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients
- Histologically confirmed invasive, unilateral breast cancer
- Indication for radiotherapy
- Indication for neoadjuvant chemotherapy with or without antibody or targeted therapies according to guidelines
- Age 18 years or older at time of consent
- Performance status 0 to 2
- No pre-existing conditions that prevent therapy
- Hormone receptor and HER2 status with no restrictions
- All tumor grades G1 to G3
- Signed informed consent for the trial
You will not qualify if you...
- Neoadjuvant treatment only with endocrine therapy
- Bilateral breast cancer
- Pregnancy or breastfeeding
- Prior chest radiotherapy
- Connective tissue diseases such as rheumatoid arthritis or thromboangiitis obliterans
- Symptomatic chronic lung diseases like fibrosis, pneumoconiosis, severe emphysema, COPD stage III
- Significant heart conditions including symptomatic coronary artery disease, prior heart attack, heart failure NYHA class II or higher, pacemaker or implanted defibrillator
- Other cancers except basal cell carcinoma or fully treated in-situ carcinomas
- Distant metastases
- Nerve damage or plexopathies in the arm on the cancer side
- Shoulder stiffness on the cancer side from any cause
- Arm lymphedema grade II or higher on the cancer side
- Any medical condition that would prevent neoadjuvant radiotherapy or expected poor compliance
- Male patients
- Patients previously assessed for chemotherapy response
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
St. Marien-Krankenhaus Ahaus
Ahaus, Germany, 48683
Actively Recruiting
2
Hochtaunus-Kliniken
Bad Homburg, Germany, 61352
Actively Recruiting
3
Sana Klinikum Lichtenberg
Berlin, Germany, 10365
Actively Recruiting
4
St. Agnes-Hospital
Bocholt, Germany, 46397
Actively Recruiting
5
Städtisches Klinikum Dessau
Dessau, Germany, 06847
Actively Recruiting
6
Universitätsfrauenklinik UK OWL, Klinikum Lippe
Detmold, Germany, 32756
Actively Recruiting
7
Universitätsklinikum Düsseldorf
Düsseldorf, Germany, 40225
Actively Recruiting
8
Niels-Stensen-Kliniken Franziskus-Hospital Harderberg
Georgsmarienhütte, Germany, 49124
Actively Recruiting
9
Sana Klinikum Hameln-Pyrmont
Hamelin, Germany, 31785
Actively Recruiting
10
Sana Klinikum Offenbach
Offenbach, Germany, 63069
Actively Recruiting
11
medius Klinik Ostfildern-Ruit
Ostfildern, Germany, 73760
Actively Recruiting
12
Leopoldina Krankenhaus Schweinfurt
Schweinfurt, Germany, 97422
Actively Recruiting
13
Johanniter-Krankenhaus Stendal
Stendal, Germany, 39576
Actively Recruiting
14
Rems-Murr-Klinikum Winnenden
Winnenden, Germany, 71364
Actively Recruiting
15
Helios Universitätsklinikum Wuppertal
Wuppertal, Germany, 42283
Actively Recruiting
16
Heinrich-Braun-Klinikum
Zwickau, Germany, 08060
Actively Recruiting
Research Team
C
Christiane Matuschek, MD Prof.
CONTACT
D
Deborah Wöstenfeld, M. A.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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