Actively Recruiting
Nerve Repair Using Hydrophilic Polymers to Promote Immediate Fusion of Severed Axons and Swift Return of Function
Led by Vanderbilt University Medical Center · Updated on 2025-10-20
18
Participants Needed
1
Research Sites
458 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Current strategies for peripheral nerve repair are severely limited. Even with current techniques, it can take months for regenerating axons to reach denervated target tissues when injuries are proximally located. This inability to rapidly restore the loss of function after axonal injury continues to produce poor clinical outcomes. The investigators propose testing the efficacy and safety of a combination therapy: polyethylene glycol (PEG) assisted axonal fusion technique to repair peripheral nerve injuries in humans.
CONDITIONS
Official Title
Nerve Repair Using Hydrophilic Polymers to Promote Immediate Fusion of Severed Axons and Swift Return of Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of a Sunderland Class 5 traumatic neuropathy (complete transection) of a digital nerve in the upper extremity
- Candidate for immediate operative repair
- Injury occurred no longer than 72 hours before repair
- Repair within 48 hours of injury requiring nerve grafting
- No significant medical conditions that prevent immediate repair
- Willingness to follow all treatment and evaluation schedules for 12 months
- Includes patients with peripheral nerve injuries complicated by vascular or orthopedic damage
You will not qualify if you...
- Injuries with gross contamination or inadequate soft tissue coverage
- Planned staged nerve repair
- Diagnosis of diabetes or neuromuscular disease
- Undergoing chemotherapy, radiation, or treatments affecting nerve or blood vessel growth
- Currently enrolled in another investigational study
- Unlikely to complete required occupational therapy
- Injury occurred outside the study time limits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
W
Wesley Thayer, MD
CONTACT
J
Julia Yao, BSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here