Actively Recruiting
Nerve Transfer to Improve Function in High Level Tetraplegia
Led by Washington University School of Medicine · Updated on 2026-03-11
30
Participants Needed
10
Research Sites
255 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
U
University of Michigan
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years postop.
CONDITIONS
Official Title
Nerve Transfer to Improve Function in High Level Tetraplegia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 80 years of age
- High cervical spinal cord injury at motor level C1-C4
- Motor complete spinal cord injury graded AIS A-B
- Plateaued spontaneous recovery for at least 6 months of non-operative therapy
- Injury occurred more than 6 months but less than 60 months prior
- Donor nerve strength of at least Medical Research Council grade 4 out of 5
- Mentally and physically able and willing to comply with study evaluations
You will not qualify if you...
- Active infection at the surgical site or systemic infection
- Any return or ongoing recovery of distal motor function
- Significant joint contractures or limited passive range of motion in the arm
- Mentally or physically unable to complete study activities
- Immunosuppressed condition
- Currently on long-term steroid therapy
- Active cancer
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 10 locations
1
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
2
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
3
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
4
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
5
Washington University in St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
6
Wake Forest Medical Center
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
7
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
8
Houston Methodist
Houston, Texas, United States, 77030
Actively Recruiting
9
University of Utah
Salt Lake City, Utah, United States, 84132
Actively Recruiting
10
University of Alberta
Edmonton, Alberta, Canada, T6G-2E1
Not Yet Recruiting
Research Team
L
Linda Koester, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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