Actively Recruiting
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
Led by Rennes University Hospital · Updated on 2026-01-05
120
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the NODAL clinical trial is to demonstrate the feasibility of new, low-cost, non-invasive biomarkers of neurodegenerative pathologies as early Alzheimer and Parkinson, based on the estimation of the multimodal connectome.
CONDITIONS
Official Title
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- French mother tongue
- Right-handed
- Education level equal to or higher than Primary School Certificate
- No medical or psychiatric condition likely to affect cognition (except diagnosis for patients)
- Affiliated with a social security scheme
- Provided informed consent
- For subjective cognitive decline-plus group: meets Jessen criteria
- For Alzheimer's patients with mild cognitive impairment: meets Albert criteria
- For newly diagnosed Parkinson's patients without cognitive deficits: meets Postuma criteria
- For Parkinson's patients with mild cognitive impairment: meets Litvan criteria
You will not qualify if you...
- MRI contraindications such as abdominal circumference plus upper limbs > 200 cm
- Having an implantable pacemaker or defibrillator
- Presence of neurosurgical clips
- Having cochlear implants
- Having neural or peripheral stimulators
- Intra-orbital or brain metallic foreign bodies
- Recent endoprostheses (<4 weeks) or osteosynthesis devices (<6 weeks)
- Claustrophobia
- Pregnant or breastfeeding women
- Adults under legal protection or deprived of liberty
- Score >2 on modified Hachinski scale (patients only)
- Dementia by McKhann criteria (patients only)
- Sensory deficits interfering with tests (patients only)
- Cognitive impairment with MoCA score < 26 (healthy volunteers only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU Rennes
Rennes, France
Actively Recruiting
Research Team
M
marie-laure gervais, Phd
CONTACT
P
Pierre-Yves JONIN, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
5
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here