Actively Recruiting
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
Led by Rennes University Hospital · Updated on 2026-01-05
120
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to find new, affordable, and non-invasive biomarkers for early detection of neurodegenerative diseases like Alzheimer's and Parkinson's. These diseases often have long early stages without symptoms, making early diagnosis difficult but important to delay loss of independence and help with future treatments. Current methods rely mainly on clinical criteria, which can delay diagnosis, so this study explores brain network patterns using advanced imaging techniques. Participants include people with early-stage Alzheimer's or Parkinson's disease and healthy volunteers. After joining the study, they will have a half-day experimental visit including clinical assessments, an MRI scan, and a cognitive task called CONFMEM, which tests how memory is affected by cognitive conflict. The study will analyze brain connectivity patterns to see if they can identify markers specific to each disease. During the visit, participants will undergo clinical evaluations, brain imaging, and cognitive testing. Researchers will measure brain connectivity graph metrics and compare them across different disease stages and healthy individuals. They will also examine the relationship between these brain measures and cognitive scores collected within six months. The study will last until December 2026 and includes follow-up assessments to better understand these neurodegenerative conditions.
CONDITIONS
Brief Title
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- French mother tongue
- Right-handed
- Education level equal to or higher than the Primary School Certificate
- Free of medical or psychiatric conditions likely to interfere with cognition (except diagnosis for patients)
- Affiliated with a social security scheme
- Provided oral and written informed consent
- For subjective cognitive decline group: meets Jessen criteria for "subjective cognitive decline-plus"
- For Alzheimer's group: meets criteria for "Mild neurocognitive disorder due to Alzheimer's disease"
- For Parkinson's de novo group: newly diagnosed Parkinson's disease without cognitive deficits
- For Parkinson's mild cognitive impairment group: Parkinson's disease with mild neurocognitive impairment
- Age between 50 and 80 years
You will not qualify if you...
- Contraindications to MRI such as abdominal circumference + upper limbs > 200 cm
- Having implantable pacemaker, defibrillator, neurosurgical clips, cochlear implants, neural or peripheral stimulators
- Intra-orbital or brain metallic foreign bodies
- Endoprostheses fitted less than 4 weeks ago or osteosynthesis devices less than 6 weeks ago
- Claustrophobia
- Pregnant or breastfeeding women
- Adults under legal protection or deprived of liberty
- Patients with modified Hachinski scale score >2
- Patients with dementia according to McKhann criteria
- Sensory deficits interfering with tests
- Healthy volunteers with cognitive impairment (MoCA score < 26)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Half a day
Participants undergo clinical assessment, an MRI scan, and perform the CONFMEM experimental task to identify biomarkers related to cognitive conflict and recognition memory.
1 visit (in-person)
Duration - Up to 6 months
Participants may have follow-up assessments up to 6 months later to correlate multimodal connectivity graph metrics with cognitive scores.
Follow-up assessments as needed
Trial Site Locations
Total: 1 location
1
CHU Rennes
Rennes, France
Actively Recruiting
Research Team
M
marie-laure gervais, Phd
P
Pierre-Yves JONIN, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
5
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