Actively Recruiting
Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment
Led by University of California, Los Angeles · Updated on 2026-05-05
70
Participants Needed
1
Research Sites
283 weeks
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI subjects and subjects with subjective memory complaints who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.
CONDITIONS
Official Title
Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Agreement to participate in the study
- 55-100 years of age
- Right-handedness
- In good general health
- Living independently
- Subjective memory complaints (self-report and positive score on MFQ)
- Katz ADL scale and Lawton iADL scale: reviewed case-by-case if not 100%, excluding those with impairment in daily functioning due to cognitive issues
- MMSE score greater than 24
- PHQ Depression score 7 or less
- Ability to read, write, and speak English fluently
- Diagnosis of mild neurocognitive disorder per DSM-5; subjective memory complaints without aMCI diagnosis reviewed case-by-case
- No change in psychotropic medication use for depression, anxiety, ADHD, or psychosis 1 month prior and during the study
You will not qualify if you...
- Unwilling or unable to provide informed consent
- Diagnosis of dementia
- Active major medical, psychiatric, or neurological disorder causing cognitive impairment
- History of alcohol or substance abuse
- Recent (less than 6 months) alcohol or substance abuse (excluding nicotine or caffeine)
- History of stroke related to memory problem, traumatic brain injury with loss of consciousness, or other neurological disorders such as epilepsy, Huntington's disease, Parkinson's disease
- Non-English speaking
- Not right-handed by self-report or evaluation
- Previous transcranial magnetic stimulation (TMS) treatment
- Poorly controlled hypertension or cardiovascular disease
- Current enrollment in memory-enhancement study or course
- Contraindications to TMS or MRI including claustrophobia, metal in body, recent surgery (within 60 days), certain implants, or abnormal MRI results
- Use of anticholinergic medications, sedating antihistamines, drugs with significant anticholinergic or antihistaminic side effects, or benzodiazepines (evaluated case-by-case)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California Los Angeles
Los Angeles, California, United States, 90024
Actively Recruiting
Research Team
S
Sonja Hiller
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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