Actively Recruiting
Neural Autoantibody Prevalence in New-onset Focal Seizures of Unknown Etiology
Led by Shen Chun-Hong · Updated on 2025-08-27
300
Participants Needed
1
Research Sites
387 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Seizure is one of the most common symptoms in autoimmune encephalitis with neuronal surface-mediated antibodies. Interestingly, some patients may exhibit new-onset seizures as the initial manifestation without fulminant sign of encephalitis, particularly in the early stage. It is essential to recognize these patients early and to perform antibody testing, as studies have reported early immunotherapy can improve their clinical outcomes. At the same time, it is important to limit the number of patients who require testing, for the sake of specificity and cost effectiveness. Thus, this prospective, multicenter study aims to identify neural antibodies in patients with focal seizures of unknown etiology, and to create a score to preselect patients requiring autoantibody testing.
CONDITIONS
Official Title
Neural Autoantibody Prevalence in New-onset Focal Seizures of Unknown Etiology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with new-onset focal epileptic seizure or epilepsy having their first seizure within the past 12 months
- Patients recruited prospectively from epilepsy centers and clinics
- No clear suspicion of autoimmune encephalitis
- Written informed consent obtained and blood samples collected
- Cerebrospinal fluid testing conducted if serum autoantibodies are detected
You will not qualify if you...
- Seizures caused by structural, infectious, genetic, or metabolic reasons
- Written informed consent not obtained
- Loss of follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
C
Chun-Hong Shen
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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