Actively Recruiting
Neural Connectivity During Therapy for Adolescent PTSD
Led by The University of Texas Health Science Center at San Antonio · Updated on 2026-01-13
180
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center at San Antonio
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy.
CONDITIONS
Official Title
Neural Connectivity During Therapy for Adolescent PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 12 to 17 years and Tanner stage 2 or above
- History of interpersonal trauma
- PTSD symptoms with a rating of 2 or higher on at least one symptom from each of the 4 clusters using the Clinician-Administered PTSD Scale for Children and Adolescents
- PTSD symptoms lasting at least one month
You will not qualify if you...
- Current or past use of psychiatric medications
- Severe suicidal or homicidal ideation
- Current hospitalization
- Receiving other psychotherapy or previous treatment with TF-CBT
- History of head injury with loss of consciousness longer than 5 minutes
- IQ below 85
- Major medical illness
- MRI contraindications such as metal in the body or braces on teeth
- Diagnosis of psychosis, bipolar 1, autism, developmental disorder, or panic disorder
- First-degree family member with psychosis or bipolar I disorder
- Substance dependence within past 3 months or frequent current drug use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT Health Department of Psychiatry
San Antonio, Texas, United States, 78229
Actively Recruiting
Research Team
A
Amy Garrett, PhD
CONTACT
N
Natalia Gomez-Giulilani
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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