Actively Recruiting
Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Led by Duke University · Updated on 2025-11-20
132
Participants Needed
1
Research Sites
229 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Individuals with chronic pain are more likely to smoke cigarettes and have more difficulty quitting smoking than the general population, in part because withdrawal from smoking can lead to temporary increases in pain. This research will examine how smoking withdrawal changes the way the brain processes pain, and whether these withdrawal-related changes interfere with the ability to stop smoking. The results of this research will provide important information that can be used to guide the development of interventions to help people with chronic pain who smoke cigarettes to quit smoking and improve their health.
CONDITIONS
Official Title
Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of chronic non-cancer low back pain lasting 6 months or more OR no history of chronic pain
- Age between 21 and 65 years
- Smoking at least 10 cigarettes per day for more than 2 years
- Own an iPhone or Android smartphone capable of running the EMA software
You will not qualify if you...
- Pain caused by cancer, rheumatoid arthritis, or complex regional pain syndrome
- Actively trying to quit smoking
- Unable to attend all required study sessions
- Significant health problems like chronic hypertension, emphysema, seizure disorder, or serious heart issues
- Conditions that make MRI unsafe (e.g., metal implants, claustrophobia)
- Use of opioids in the past 90 days
- Alcohol or substance use disorder in the past year
- Positive urine test for illegal drugs other than marijuana
- Daily use of alcohol or marijuana
- History of psychotic disorder or current unstable psychiatric disorder
- Regular use of non-cigarette tobacco products or e-cigarettes
- Major surgery in the past 6 months or planned during the study
- Breath alcohol level above 0.0 (one chance to rescreen if failed)
- Recently quit smoking for more than 3 days
- Pregnancy or planning to become pregnant
- Any factors that may harm the participant or study integrity, such as legal issues, uncontrolled psychiatric disorder, head/neck injury, or certain medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Duke North Pavilion
Durham, North Carolina, United States, 27705
Actively Recruiting
Research Team
C
Clinical Research Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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