Study of Plasma Exosomal MicroRNAs as Biomarkers for Suicidality and Treatment Effects in Adolescents and Young Adults with Depression

What this Trial Is About

Researchers are studying adolescents and young adults with depression and suicidal thoughts to identify biological markers called microRNAs that may help understand these conditions better. The study aims to improve medical and psychiatric care by exploring the relationship between these biomarkers and depressive and suicidal behaviors. It also evaluates how standard treatments for depression affect symptoms and these biomarkers. Participants diagnosed with Major Depressive Disorder will have blood samples collected at the start and again after six weeks of treatment. The study involves genetic testing to identify markers related to suicide risk and treatment outcomes. Participants return for a follow-up visit at six weeks for a second blood draw and assessments. During the study, participants will undergo clinical evaluations and blood tests to analyze their depressive symptoms and suicidal behaviors. Researchers will assess clinical features using rating scales and monitor changes over six weeks. The total participation time includes the initial visit and a follow-up at six weeks to gather outcome data and study the effects of treatment on biomarkers.

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents