Study of Deep Brain Stimulation Effects on Sleep Problems in Parkinsons Disease Patients Using Wearable Sleep Monitoring

What this Trial Is About

Researchers are investigating how deep brain stimulation DBS of the subthalamic nucleus STN affects sleep problems in people with Parkinsons disease PD. While DBS is known to help motor symptoms, its effects on sleep and the related brain activity are not well understood. This study aims to explore how DBS changes sleep patterns, brain signals, and clinical outcomes, using advanced wearable monitors and brain recordings to better understand sleep regulation in PD patients. Participants will be patients with Parkinsons disease who have bilateral STN-DBS devices. Before surgery, clinical assessments and two nights of sleep monitoring with wearable polysomnography PSG will be done. After surgery, motor symptoms will be controlled by optimizing DBS settings at one month. Follow-up visits at 3, 6, and 12 months will include two nights of in-hospital PSG and brain signal recordings, first without stimulation and then with DBS turned on. Later, an adaptive DBS algorithm will be tested for one month, followed by PSG monitoring and sleep quality assessments. Afterwards, routine DBS will be used for one month, with further sleep monitoring to compare effects. Throughout the study, participants will undergo clinical evaluations for motor and non-motor symptoms, detailed sleep studies, and brain signal analysis. Researchers will analyze sleep stages, muscle relaxation during sleep, and brain activity to identify markers that predict sleep improvement. The study will also test whether adaptive DBS can better regulate sleep than standard DBS. The main outcomes measured are the duration of REM sleep and subjective sleep quality over 12 months. This work aims to guide future personalized DBS treatments for sleep issues in Parkinsons disease.

Neural Mechanisms and Clinical Applications of DBS for Modulating Sleep Dysregulation in PD