Actively Recruiting
Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
Led by Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Updated on 2025-12-12
200
Participants Needed
1
Research Sites
232 weeks
Total Duration
On this page
Sponsors
H
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.
CONDITIONS
Official Title
Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years old
- Clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome with a symptom score greater than 12
- Currently experiencing fatigue or brain fog as assessed by symptom checklists and questionnaires
You will not qualify if you...
- Neurological disorders such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or other neuromuscular diseases
- Diagnosed severe psychiatric diseases including depression and schizophrenia
- Congestive heart failure
- Peripheral artery disease with claudication
- Cancer
- Pulmonary or renal failure
- Unstable angina
- Uncontrolled hypertension above 190/110 mmHg
- Severe aphasia
- Orthopedic or pain conditions
- Exposure to metal or metal implants
- Immunomodulatory therapy started less than 6 months before the study
- For healthy controls: hospitalization due to SARS-CoV-2 infection or any of the above conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21201
Actively Recruiting
Research Team
A
Anthony Gonzalez
CONTACT
V
Vikram Chib, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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