Actively Recruiting

Phase Not Applicable
Age: 18Years - 88Years
All Genders
NCT06214923

Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)

Led by University of Maryland, Baltimore · Updated on 2026-01-26

78

Participants Needed

2

Research Sites

137 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.

CONDITIONS

Official Title

Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)

Who Can Participate

Age: 18Years - 88Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 88 years
  • English speaker (written and spoken)
  • Have temporomandibular disorder (TMD) for at least 3 months
  • TMD Grade Chronic Pain Scale (GCPS) score of 0 or higher
Not Eligible

You will not qualify if you...

  • Present or past degenerative neuromuscular disease
  • Cardiovascular, neurological, pulmonary, kidney, or liver diseases
  • History of cancer within the past 3 years
  • Cervical pain conditions such as stenosis or radiculopathy
  • Personal or first-degree family history of mania, schizophrenia, or other psychoses
  • Severe psychiatric conditions leading to hospitalization within the last 3 years
  • Use of antipsychotic medications
  • Lifetime alcohol or drug dependence, or abuse within the past 3 months
  • Pregnancy or breastfeeding
  • Color blindness
  • Impaired or uncorrected hearing
  • Non-dominant hand usage
  • Facial trauma within the last 6 weeks or severe facial trauma within the last 2 to 3 months
  • Conditions interfering with VR mask placement such as trauma, burn, or infection
  • History of severe motion sickness
  • Non-removable head coverings, artificial hair, certain braids, or dreadlocks
  • History of fainting
  • History of angioedema
  • Failed drug test for opiates, cocaine, methamphetamines, or amphetamines

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

Luana Colloca

Baltimore, Maryland, United States, 21201-1512

Actively Recruiting

2

University of Maryland

Baltimore, Maryland, United States, 21201-1512

Actively Recruiting

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Research Team

R

Research Coordinator

CONTACT

K

Katia Matychak, MS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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